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‘Opioid’, opioids, pain, language and communication
Anaesthesia and Intensive Care, 2022Over the last decades public discussion of opioids has changed radically. Opioid was once a word largely restricted to professional medical and pharmacological use for the treatment and management of pain. But propelled by the rapidly growing international wave of opioid use and overuse, it is now part of a much wider public discussion that covers more
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Opioid genetics in the context of opioid switching
Current Opinion in Supportive & Palliative Care, 2012On a population level, there is no difference in terms of efficacy or side-effects between any of the strong opioids. On an individual level, however, there is marked variation in response to opioids. This review presents some of the recent advances in opioid pharmacogenetic studies.A growing number of genes have been studied in a number of different ...
Joanne, Droney, Julia, Riley, Joy, Ross
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Clinical and Experimental Pharmacology and Physiology, 1995
SUMMARY1. The central nervous system in mammals is able to react to painful stimuli at many levels that are involved in transmission, modulation and sensation of pain. Endogenous opioid peptides and their receptors are located at key points in pain pathways, and response to pain can be modulated by local application of opioids at many sites. Mechanisms
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SUMMARY1. The central nervous system in mammals is able to react to painful stimuli at many levels that are involved in transmission, modulation and sensation of pain. Endogenous opioid peptides and their receptors are located at key points in pain pathways, and response to pain can be modulated by local application of opioids at many sites. Mechanisms
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Genetics of pain, opioids, and opioid responsiveness
Metabolism, 2010Pain is an integral part of the defense mechanisms required for survival. Several hereditary syndromes of complete or almost complete insensitivity to pain have been identified and include channelopathy-associated pain insensitivity, of which the most likely candidate gene is the α-subunit of the voltage-gated sodium channel known as Na(v)1.7.
Johanne, Tremblay, Pavel, Hamet
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Opioids, opioid receptors, and the immune response
Drug and Alcohol Dependence, 2001It is now clear that opioid receptors participate in the function of the cells of the immune system, and evidence suggests that opioids modulate both innate and acquired immune responses. We review literature here which establishes that mu-, kappa-, and delta-opioid compounds alter resistance to a variety of infectious agents, including the Human ...
L, McCarthy +4 more
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Opioids and Opioid Receptors in Peripheral Tissues
Scandinavian Journal of Gastroenterology, 1987Opioid peptides belonging to the enkephalin, beta-endorphin or dynorphin family, acting on specific opiate receptors may be found in peripheral tissues. Enkephalins have a widespread peripheral distribution, while beta-endorphin and dynorphin may be found locally in the enteric nervous system.
T, Hedner, J, Cassuto
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Opioid receptors and endogenous opioid peptides
Medicinal Research Reviews, 1991The field to be reviewed is now 16 years old and is based on knowledge dating back centuries. It is therefore evident that an exhaustive review is impossible. The author plans to discuss areas likely to be of interest to the readers of this journal.
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Pharmacology & Therapeutics, 2001
Opioid peptides and exogenous opioids such as morphine are known to exert important cardiovascular effects. However, until recently, it was not appreciated that activation of specific receptors results in a potent cardioprotective effect to reduce infarct size in experimental animals and to reduce cell death in isolated cardiomyocytes.
J E, Schultz, G J, Gross
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Opioid peptides and exogenous opioids such as morphine are known to exert important cardiovascular effects. However, until recently, it was not appreciated that activation of specific receptors results in a potent cardioprotective effect to reduce infarct size in experimental animals and to reduce cell death in isolated cardiomyocytes.
J E, Schultz, G J, Gross
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Perioperative Opioids, the Opioid Crisis, and the Anesthesiologist
Anesthesiology, 2022Daniel B. Larach +2 more
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