Results 71 to 80 of about 166,726 (313)
Harm Reduction JournalBackground Illicit opioids, including fentanyl, are linked to unprecedented levels of overdose in Canada and elsewhere. The risks associated with illicit opioids can include high potency, unpredictable concentration and the unexpected presence in other ...
Bruce Wallace +12 more
doaj +1 more source
Morphine for the Treatment of Pain in Sickle Cell Disease
The Scientific World Journal, 2015 Pain is a hallmark of sickle cell disease (SCD) and its treatment remains challenging. Opioids are the major family of analgesics that are commonly used for treating severe pain.
Mihir Gupta +3 more
doaj +1 more source
Status and Rationality of Opioid Use in Lung Cancer Patients: A Single Center Retrospective Study
Chinese Journal of Lung Cancer, 2020 Background and objective Cancer pain affect the physical activity, psychological state and quality of life seriously, and even shortened the survival time of patients.
Wenjuan SUN +4 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann +10 more
wiley +1 more source
Use of Opioids in Clinical Pratice [PDF]
Opioids have been traditionally used in clinical practice to treat various symptoms and diseases, including pain, myocardial infarction and cough.
Kashu, Riku
core
, 2007 Opioids can be administered parenterally when the oral route is not suitable. Continuous subcutaneous infusion is safe, comfortable and effective. Morphine and diamorphine are the commonly used World Health Organization (WHO) step III opioids.
Jeremy R. Johnson
core +1 more source
Incidence and Predictive Factors for Prolonged Use of Opioid Medication After Foot and Ankle Surgery
Foot & Ankle Orthopaedics, 2018 Category: Other Introduction/Purpose: The purpose of this study is to evaluate the incidence and factors predictive for patients’ needs for opioid pain medication longer than 2 weeks after orthopaedic foot/ankle surgery in a single surgeon’s practice at ...
Jamal Ahmad MD
doaj +1 more source
The dark side of opioids in pain management: basic science explains clinical observation
PAIN Reports, 2016 . Introduction:. In the past 2 decades, opioids have been used increasingly for the treatment of persistent pain, and doses have tended to creep up. As basic science elucidates mechanisms of pain and analgesia, the cross talk between central pain and ...
Cyril Rivat, Jane Ballantyne
doaj +1 more source
Arthroscopy, EarlyView.Purpose To compare perioperative complications and revision surgery rates between following primary rotator cuff repair among patients with nontobacco nicotine dependence (NTND), no nicotine dependence, and traditional tobacco‐related nicotine dependence.
Samuel A. Florentino +6 more
wiley +1 more source
Health disparities in chronic liver disease
Hepatology, EarlyView., 2022 Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian +3 more
wiley +1 more source