Results 71 to 80 of about 181,981 (311)
Annals of Neurology, EarlyView.Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau +8 more
wiley +1 more source
Status and Rationality of Opioid Use in Lung Cancer Patients: A Single Center Retrospective Study
Chinese Journal of Lung Cancer, 2020 Background and objective Cancer pain affect the physical activity, psychological state and quality of life seriously, and even shortened the survival time of patients.
Wenjuan SUN +4 more
doaj +1 more source
Harm Reduction JournalBackground Illicit opioids, including fentanyl, are linked to unprecedented levels of overdose in Canada and elsewhere. The risks associated with illicit opioids can include high potency, unpredictable concentration and the unexpected presence in other ...
Bruce Wallace +12 more
doaj +1 more source
Incidence and Predictive Factors for Prolonged Use of Opioid Medication After Foot and Ankle Surgery
Foot & Ankle Orthopaedics, 2018 Category: Other Introduction/Purpose: The purpose of this study is to evaluate the incidence and factors predictive for patients’ needs for opioid pain medication longer than 2 weeks after orthopaedic foot/ankle surgery in a single surgeon’s practice at ...
Jamal Ahmad MD
doaj +1 more source
, 2014 Opioids have been used for thousands of years for the treatment of pain. It was revealed that the drug bound to very special areas of the brain which were subsequently called morphine receptors. Until now, a wide range of the these receptors and subtypes
Ahmadi, Arash
core
Angewandte Chemie International Edition, EarlyView.Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann +10 more
wiley +1 more source
The dark side of opioids in pain management: basic science explains clinical observation
PAIN Reports, 2016 . Introduction:. In the past 2 decades, opioids have been used increasingly for the treatment of persistent pain, and doses have tended to creep up. As basic science elucidates mechanisms of pain and analgesia, the cross talk between central pain and ...
Cyril Rivat, Jane Ballantyne
doaj +1 more source
Effectiveness and risks associated with long-term use of opioids in chronic pain.
, 2018 Long-term use of opioids is prevalent in medicine due to the increasing diagnosis of chronic pain. This thesis evaluates how effective their use is in long-term treatment and adverse effects associated with opioid use.általános orvosangolegységes ...
Asante Boateng, Bendelyn
core
The effect of subcutaneous naloxone on experimentally induced pain [PDF]
, 2008 The heat pain threshold was assessed in 32 healthy participants after a mild burn on the dorsal surface of each hand, after injection of an opioid antagonist (80 μg naloxone) or vehicle alone (0.2 mL saline) into the burnt skin of 1 hand, and after ...
Hammond, G.R. +2 more
core
Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes
Journal of Applied Polymer Science, EarlyView.Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis +1 more
wiley +1 more source