Results 71 to 80 of about 186,280 (306)

Parenteral opioids

, 2007
Opioids can be administered parenterally when the oral route is not suitable. Continuous subcutaneous infusion is safe, comfortable and effective. Morphine and diamorphine are the commonly used World Health Organization (WHO) step III opioids.
Jeremy R. Johnson
core   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Neuropsychiatric manifestations due to anticholinergic agents and anabolic steroids ingestion: A case series and literature review

Neuropsychopharmacology Reports
Anticholinergic toxicity is a common occurrence in the emergency room, making it crucial for emergency clinicians to have a good understanding of this toxidrome.
Homa Talabaki, Mahkameh Soltani, Ali Abbasi, Vahid Sharifi, Narges Salehi, Zakaria Zakariaei   +5 more
doaj   +1 more source

Opioids in Cancer Pain

, 2007
Opioids in Cancer Pain outlines the opioids available for the management of cancer pain, examining the evidence for their use, discussing how they are best used and outlining the side effects.

core   +1 more source

Effect of Opioids on Survival in Patients with Cancer

, 2022
Opioids are commonly used for pain management in patients with cancer. They have a range of unwanted effects, including some that potentially influence cancer growth.
Boland, Jason W., Jason W. Boland
core   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Recommendations for the use of opioids in Brazil: Part III. Use in special situations (postoperative pain, musculoskeletal pain, neuropathic pain, gestation and lactation)

Revista Dor, 2014
BACKGROUND AND OBJECTIVES: The use of opioids as first and second line agents to adequately treat pain requires systematization in different clinical syndromes which course with acute pain.
Durval Campos Kraychete, José Tadeu Tesseroli de Siqueira, Telma Regina Mariotto Zakka, João Batista Santos Garcia   +3 more
doaj   +2 more sources

Use of immediate-release opioids as supplemental analgesia during management of moderate-to-severe chronic pain with buprenorphine transdermal system [PDF]

, 2017
Sanford Silverman,1,2 Robert B Raffa,3,4 Marc J Cataldo,5 Monica Kwarcinski,5 Steven R Ripa5 1Comprehensive Pain Medicine, Pompano Beach, 2Department of Integrated Medical Sciences, Charles E Schmidt College of Medicine, Florida Atlantic University, Boca
Kwarcinski, Monica, Raffa RB, Robert B Raffa, Marc Cataldo, Ripa, Steven R., Silverman, Sanford, Steven R. Ripa, Sanford Silverman, Monica Kwarcinski, Kwarcinski M, Ripa SR, Cataldo, Marc, Silverman S, Cataldo MJ, Raffa, Robert B   +14 more
core   +1 more source