Results 51 to 60 of about 166,726 (313)

Opioid Epidemics

SSRN Electronic Journal, 2019
In this paper, I propose an economic theory that addresses the epidemic character of opioid epidemics. I consider a community in which individuals are heterogenous with respect to the experience of chronic pain and susceptibility to addiction and live through two periods.
openaire   +5 more sources

A Fentanyl‐Responsive Microneedle Patch for Harm Reduction

Advanced Science, EarlyView.
A fentanyl‐responsive microneedle patch is developed as a self‐regulating overdose intervention that releases naloxone upon detecting fentanyl. The system employs aptamer‐functionalized nanoparticles embedded in a swellable polymer matrix to enable rapid, on‐demand drug delivery through the skin.
Penghui Zhao, Zerui Zhou, Tyler Wolter, Huanqing Niu, Yuanzhi Bian, Chixia Tian, Chun Xu, Chenming Zhang, Juhong Chen, Matthew W. Buczynski, Wujin Sun   +10 more
wiley   +1 more source

Opioids and cancer survival: are we looking in the wrong place?

BJA Open, 2022
There is a controversial narrative in the anaesthetic literature suggesting that anaesthetic technique (including opioids) may be detrimental to survival after tumour resection. The initial observations were retrospective. Several prospective studies are
Despina Giakomidi, Mark F. Bird, David G. Lambert   +2 more
doaj   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Determinants of nurses' intention to administer opioids for pain relief [PDF]

, 2001
A statewide cross-sectional survey was conducted in Australia to identify the determinants of registered nurses' intention to administer opioids to patients with pain.
Anne M. Walsh, McDowell, Jan K., Patsy M. Yates, Najman, J. M., Skerman, H. M., Fentiman, Belinda J., Yates, P. M., Belinda J. Fentiman, Walsh, A. M., Nash, R., Jan K. McDowell, Fentiman, B. J., Dewar, A. M., Yates, Patsy, Helen E. Edwards, Anne Dewar, McDowell, J. K., Walsh, Anne M., Nash, Robyn E., Skerman, Helen M., Helen M. Skerman, Najman, Jackob M., Jake M. Najman, Edwards, Helen E., Edwards, H. E., Dewar, Anne M., Robyn E. Nash   +26 more
core   +1 more source

Postsurgical Opioid Prescribing Among Injured Workers in Washington State: 2017–2020 Trends and Policy Effects

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Introduction The widespread adoption of longer duration opioid prescribing for acute pain management following surgeries has coincided with concerning increases in misuse, dependence, and overdose. We evaluated the impact of voluntary opioid prescribing guidelines and concurrent state pharmacy rules on prescribing trends following surgeries ...
John R. Haight, Deborah Fulton‐Kehoe, Anjum Hajat, Joel D. Kaufman, Gary M. Franklin   +4 more
wiley   +1 more source

Neurological drugs and opioids for pain management [PDF]

, 2012
20.1 Epilepsy and an introduction to drugs used to treat\ud 20.1.1 Introduction to epilepsy\ud 20.1.2 Treatment of partial seizures\ud 20.1.3 Treatment of generalised seizures\ud 20.1.4 Treatment of status epilepticus\ud 20.2 Neurodegenerative disorders;
Doggrell, Sheila
core  

Opioids in clinical practice [PDF]

, 2020
The treatment of pain improves quality of life. Opioids are commonly prescribed painkillers. The side effectsof opioids depend on the route of administration, dosage, drug metabolism, comorbid diseases and thepatient’s general condition.
Perlińska, Maria; Students' Scientific Society, Poznan University of Medical Sciences, Poznan, Poland, Woźniak, Martyna; Students' Scientific Society, Poznan University of Medical Sciences, Poznan, Poland, Gorzelinska, Lidia; Palliative Medicine In-Patient Unit, University Hospital of Lord’s Transfiguration, Poznan University of Medical Sciences, Os. Rusa 55, 61-245 Poznan, Poland, Zaporowska-Stachowiak, Iwona; Chair and Department of Palliative Medicine, Pharmacotherapy in Palliative Care Laboratory, Poznan University of Medical Sciences, University Clinical Hospital, Poznan, Poland; Palliative Medicine In-Patient Unit, University Hospital of Lord’s Transfiguration, Poznan University of Medical Sciences, Os. Rusa 55, 61-245 Poznan, Poland, Dziuba, Gabriela; Students' Scientific Society, Poznan University of Medical Sciences, Poznan, Poland, Mikołajczak, Anna; Students' Scientific Society, Poznan University of Medical Sciences, Poznan, Poland, Oduah, Mary-Tiffany Adannia; English Students’ Research Association, Poznan University of Medical Sciences, Jackowskiego 41, 60-512 Poznan, Poland, Celichowska, Magdalena; Students' Scientific Society, Poznan University of Medical Sciences, Poznan, Poland, Sopata, Maciej; Palliative Medicine In-Patient Unit, University Hospital of Lord’s Transfiguration, Poznan University of Medical Sciences, Os. Rusa 55, 61-245 Poznan, Poland   +8 more
core   +2 more sources

Abuse and Diversion of Immediate Release Opioid Analgesics as Compared to Extended Release Formulations in the United States.

PLoS ONE, 2016
BackgroundTherapeutic use and abuse of prescription opioids in the United States increased substantially between 1990 and 2010. The Centers for Disease Control estimated deaths related to pharmaceutical opioids reached nearly 19,000 in 2014.
Janetta L Iwanicki, S Geoff Severtson, Heather McDaniel, Andrew Rosenblum, Chunki Fong, Theodore J Cicero, Matthew S Ellis, Steven P Kurtz, Mance E Buttram, Richard C Dart   +9 more
doaj   +1 more source

Essential, Yet Precarious, Mistreated, Sick and Medicalized: A Sequential Explanatory Mixed‐Methods Study on Homecare Aides in Spain

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Homecare aides (HCAs) are professional non‐family caregivers, who support dependent individuals to live at home with dignity; yet in Spain they remain understudied and vulnerable, often facing precarious working conditions. We aimed to characterize HCAs’ employment, living conditions, health, and exposure to workplace violence and ...
Albert Navarro‐Giné, Pedro Ferrer‐Rosende, Maria Feijoo‐Cid, Sergio Salas‐Nicás, Laura Esteve‐Matalí, Valeria Stuardo‐Ávila, María Isabel Fernández‐Cano   +6 more
wiley   +1 more source