Results 221 to 230 of about 4,457,338 (303)

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu, Qiang Long, Yihao Liu, Xiuqiao Sun, Baoding Zhang, Binxin Liao, Weibin Wu, Wangxi Hai, Pei Zhang, Wenhua Lian, Yuewen Zhu, Zheng Wang, Caisheng Wu, Xianming Deng, Hélder A. Santos, Xiaofeng Ye   +15 more
wiley   +1 more source

Non-invasive detection of metastatic papillary thyroid carcinoma after radical surgery using salivary metabolomic biomarkers. [PDF]

Arch Endocrinol Metab
Yu F, Pan J, Zhang L, Li S, Zhang C, Fu J, Zhou P, Wang J, Yao X, Ni Y, Zhang A, Meng Q, Yang R, Xu L, Wang F, Wang J, Shi L.   +16 more
europepmc   +1 more source

Interfacial Behavior of Methane in Methane/p‐Xylene/Water Systems: First Principles Inspected Using Neutron Imaging and Molecular Dynamics Simulations

Advanced Materials Interfaces, Volume 13, Issue 6, 16 March 2026.
Pressurized gases reduce interfacial tension (IFT) at the gas‐liquid interfaces, their influence on the liquid–liquid interfaces remains unclear. For model compounds methane, water, and p‐xylene, neutron imaging observation of pressurized three‐phase systems is combined with Molecular Dynamics simulations.
Martin Melčák, Tereza‐Markéta Durďáková, Petr Číhal, Jonatan Šercl, Jongmin Lee, Pierre Boillat, Jan Heyda, Pavel Trtik, Ondřej Vopička   +8 more
wiley   +1 more source

Metabolomic characteristics and mechanisms of subgingival plaque in MASLD patients with periodontitis. [PDF]

Metabolomics
Zhu J, He H, Li Y, Li Y, Feng Z, Yuan J, Liu L, Shen Q, Baishan J, Song T, Li Z.   +10 more
europepmc   +1 more source

Figure 3: OPLS-DA permutation.

semanticscholar   +1 more source

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Determinação do teor de biodiesel de Mafurra e Crambe em misturas com diesel por RMN de 1H e regressão multivariada por OPLS E OPLS-DA [PDF]

, 2020
openaire   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, Volume 13, Issue 16, 18 March 2026.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Serum biomarker screening and metabolic profiling analysis of nonalcoholic fatty liver disease patients using untargeted metabolomics and machine learning techniques. [PDF]

Front Mol Biosci
Dan L, Shi H, Cao L, Li X, Kong L, You X, Liu W, Hao Y, Wang D, Song H, Mu J, Li Q.   +11 more
europepmc   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source