Osteopenia-osteoporosis discrimination in postmenopausal women by 1H NMR-based metabonomics.
PLoS ONE, 2019 This is a report on how 1H NMR-based metabonomics was employed to discriminate osteopenia from osteoporosis in postmenopausal women, identifying the main metabolites associated to the separation between the groups. The Assays were performed using seventy-
T A Pontes +4 more
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Gene polymorphisms and motor levodopa‐induced complications in Parkinson's disease
Brain and Behavior, 2020 Objective The aim of the study was to evaluate the association of individual and combined single‐nucleotide polymorphisms in brain‐derived neurotrophic factor (BDNF), dopamine transporter (DAT), and catechol‐O‐methyltransferase (COMT) genes with the ...
Małgorzata Michałowska +7 more
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Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer [PDF]
, 2016 Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation.
Chater, E +13 more
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Circulating miRNAs as predictive biomarkers of type 2 diabetes mellitus development in coronary heart disease patients fromt he CORDIOPREV study [PDF]
, 2018 Circulating microRNAs (miRNAs) have been proposed as type 2 diabetes biomarkers, and they may be a more sensitive way to predict development of the disease than the currently used tools.
Alcalá Díaz, Juan Francisco +13 more
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A Comparative Study on Processed Panax ginseng Products Using HR-MAS NMR-Based Metabolomics
Molecules, 2020 Panax ginseng is processed to diversify efficacy. Four processed ginsengs containing white ginseng (WG), tae-geuk ginseng (TG), red ginseng (RG), and black ginseng (BG) were analyzed using nuclear magnetic resonance (NMR) spectroscopy for screening ...
Dahye Yoon +5 more
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Metabolomic evaluation of Mitomycin C and rapamycin in a personalized treatment of pancreatic cancer [PDF]
, 2014 In a personalized treatment designed for a patient with pancreatic cancer resistant to other treatments, the success of Mitomycin C (MMC) has been highlighted.
Armitage, Emily G. +8 more
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Acta Pharmaceutica, 2018 Flow-injection mass spectrometry (FIMS) coupled with a chemometric method is proposed in this study to profile and distinguish between rhizomes of Smilax glabra (S. glabra) and Smilax china (S. china). The proposed method employed an electrospray-time-of-
Liang Jian +7 more
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Deletion of TSPO resulted in change of metabolomic profile in retinal pigment epithelial cells [PDF]
, 2019 Age-related macular degeneration is the main cause of vision loss in the aged population worldwide. Drusen, extracellular lesions formed underneath the retinal pigment epithelial (RPE) cells, are a clinical feature of AMD and associated with AMD ...
Abdulwahab Alamri +7 more
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International Journal of Nanomedicine, 2022 Feng Gu,1,2,* Shan Hu,3,* Yunjian Wu,4,* Changyu Wu,4 Ying Yang,5 Bing Gu,6 Hong Du1 1Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People’s Republic of China; 2Department of ...
Gu F +6 more
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Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. [PDF]
, 2017 Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading cause of mortality and morbidity worldwide. The aim of this study was to investigate the sex dependency of circulating metabolic profiles in COPD.Serum from healthy ...
Erle, David J +11 more
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