Results 51 to 60 of about 291,003 (354)

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

High Burden of Cardiovascular Disease and Mental Health Illness Comorbidity in Urban Haiti

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background People living in low‐income settings facing humanitarian crises are at risk for comorbid cardiovascular disease (CVD) and mental health (MH) illness, yet there are limited population‐based data available.
Lily D. Yan, Miranda Metz, Rodney Sufra, Reichling St Sauveur, Kelly Celestin, Erline Hilaire, Suzanne Edwidge Marcellin, Sarine Auguste, Anju Ogyu, Catherine Bennett, Serena Koenig, Lindsey Reif, Jessy Dévieux, Marie Marcelle Deschamps, Jean W. Pape, Vanessa Rouzier, Margaret L. McNairy   +16 more
doaj   +1 more source

Staphylococcus aureus bacteraemia in Gauteng academic hospitals, South Africa

International Journal of Infectious Diseases, 2015
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) infections are responsible for longer hospital stays, increased hospital costs, and poorer outcomes compared to methicillin-sensitive S. aureus (MSSA) infections.
Melony C. Fortuin-de Smidt, Ashika Singh-Moodley, Rubeina Badat, Vanessa Quan, Ranmini Kularatne, Trusha Nana, Ruth Lekalakala, Nelesh P. Govender, Olga Perovic   +8 more
doaj   +1 more source

Prevalence and distribution of Entamoeba species in a rural community in northern South Africa

Food and Waterborne Parasitology, 2020
Amoebiasis occurs worldwide and affects about 20–50 million people annually. Stool samples were collected from patients attending different rural clinics in Northern South Africa in the present study. Microscopic examination was performed for the initial
Amidou Samie, Leah Mahlaule, Peter Mbati, Tomoyoshi Nozaki, Ali ElBakri   +4 more
doaj   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Effectiveness of community‐based hypertension management on hypertension in the urban slums of Haiti: A mixed methods study

The Journal of Clinical Hypertension
Hypertension is a leading contributor to mortality in low‐middle income countries including Haiti, yet only 13% achieve blood pressure (BP) control.
Reichling St Sauveur, Rodney Sufra, Marie Christine Jean Pierre, Vanessa Rouzier, Fabiola Preval, Serfine Exantus, Mirline Jean, Josette Jean, Guyrlaine Pierre‐Louise Forestal, Obed Fleurijean, Nour Mourra, Anju Ogyu, Rodolphe Malebranche, Jean Pierre Brisma, Marie M. Deschamps, Jean W. Pape, Radhika Sundararajan, Margaret L. McNairy, Lily D. Yan   +18 more
doaj   +1 more source

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Prevalence and genetic characterization of Giardia lamblia in relation to diarrhea in Limpopo and Gauteng provinces, South Africa

Parasite Epidemiology and Control, 2020
Background: Very few studies have determined the prevalence and assemblage distribution of Giardia lamblia in South Africa. The present study aimed to ascertain the prevalence of G.
Amidou Samie, Nicoline F. Tanih, Itumeleng Seisa, Mapaseka Seheri, Jeffrey Mphahlele, Ali ElBakri, Peter Mbati   +6 more
doaj   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source