Results 71 to 80 of about 583,244 (282)

Genomic evidence for the evolution of Streptococcus equi : host restriction, increased virulence, and genetic exchange with human pathogens [PDF]

, 2009
The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered. Streptococcus equi subspecies equi (S.
Parkhill Julian, Maskell, Duncan, Kehoe Michael, Robinson, Carl, Maiden, MC, Spratt, BG, Bason, Nathalie C., Aanensen, David M., Simmonds, M, Aanensen David M., Romain Paillot, Jourdan Thibaud, Willey, David, Maskell Duncan J., Aanensen, David, Katy Webb, Nathalie C Bason, Nancy E Holroyd, Ainslie, F, Maskell, DJ, Robinson Carl, Holden, Matthew, Simmonds Mark, Paillot Romain, Steward, KF, Jourdan, Thibaud, David M Aanensen, Bentley Stephen D., Jolley Keith A., Neil Chanter, Quail, Michael A., Stephen D Bentley, Webb, Katy, Holden, MT, Maiden Martin C. J., Julian Parkhill, Brooks Karen, Spratt Brian G., Maiden, MCJ, Fern Ainslie, Mark Simmonds, Keith A Jolley, Spratt, Brian, Holroyd, NE, Parkhill, Julian, Heather Zoe, Chanter, N, Michael Kehoe, Jolley, KA, David Willey, Bentley, Stephen, Ainslie, Fern, Quail, MA, Waller, Andrew S., Sanders Mandy, Waller, AS, Heather, Zoe, Waller, Andrew, Parkhill, J, Bason, NC, Sanders, M, Carl Robinson, Bason Nathalie C., Steward, Karen, Brooks, Karen, Bentley, Stephen D., Paillot, R, Wessels, Michael, Maiden, Martin, Holden, Matthew T. G., Zoe Heather, Robinson, C, Mungall Karen, Steward, Karen F., Quail Michael A., Paillot, Romain, Sanders, Mandy, Quail, Michael, Bason, Nathalie, Holroyd, Nancy, Maiden, Martin C. J., Andrew S Waller, Jolley, Keith A., Willey, D, Brian G Spratt, Chanter Neil, Mungall, K, Webb, K, Holden, MTG, Matthew T G Holden, Holroyd Nancy E., Kehoe, M, Karen F Steward, Maskell, Duncan J., Heather, Z, Holden Matthew T. G., Bentley, SD, Duncan J Maskell, Chanter, Neil, Aanensen, DM, Karen Brooks, Thibaud Jourdan, Brooks, K, Ainslie Fern, Steward Karen F., Holroyd, Nancy E., Mandy Sanders, Michael A Quail, Spratt, Brian G., Willey David, Simmonds, Mark, Waller Andrew S., Mungall, Karen, Webb Katy, Karen Mungall, Jourdan, T, Kehoe, Michael, Martin C J Maiden, Jolley, Keith   +118 more
core   +1 more source

Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population‐Based Study and Gut Microbiota Analysis

Advanced Science, EarlyView.
Frequent sweetened beverage consumption is associated with accelerated biological aging in a large Chinese population. Five gut microbial genera are consistently enriched in both frequent sweetened beverage consumers and individuals with accelerated aging and show significant mediating effects, suggesting a potential microbiota‐related pathway linking ...
Yuwei Shi, Xinmei Li, Yufan Hao, Qiaoyu Wu, Yuji Yu, Siyu Li, Nuo Xu, Yi‐Hsuan Wu, Eunhye Lee, Chi Chang, Emily Hu, Ying Lu, Elizabeth Delzell, Ann W. Hsing, Shankuan Zhu   +14 more
wiley   +1 more source

Bacterial Pathogens Causing Pneumonia Post Hematopoietic Stem Cell Transplant: The Chronic GVHD Population

, 2023
Allogeneic stem cell transplantation is a lifesaving treatment for many malignancies. Post-transplant patients may suffer from graft versus host disease in the acute and/or the chronic form(s).
Cynthia Schmidt, Andrea Zimmer, Ruxana T. Sadikot, Said Chaaban, Vijaya Raj Bhatt   +4 more
core   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Genome Assemblies of Two Rare Opportunistic Yeast Pathogens: Diutina rugosa (syn. Candida rugosa) and Trichomonascus ciferrii (syn. Candida ciferrii)

G3: Genes, Genomes, Genetics, 2019
Infections caused by opportunistic yeast pathogens have increased over the last years. These infections can be originated by a large number of diverse yeast species of varying incidence, and with distinct clinically relevant phenotypic traits, such as ...
Verónica Mixão, Ester Saus, Antonio Perez Hansen, Cornelia Lass-Florl, Toni Gabaldón   +4 more
doaj   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +2 more sources

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source