Results 121 to 130 of about 38,225 (233)

Effects of Proline and Glycine on the Cnidocyte Discharge of Hydra magnipapillata [PDF]

, 2015
The sense of taste enables animals to utilize environmental cues to detect favorable foods. Through specialized sensory receptors, Cnidarians employ stinging cells called cnidocytes to perform a variety of activities such as locomotion, capturing prey ...
Appleton, Janine R
core   +1 more source

Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor

Angewandte Chemie International Edition, Volume 65, Issue 18, 27 April 2026.
Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp, Quentin Bertrand, Matilde Trabuco, Anna Duran‐Corbera, Maria Tindara Ignazzitto, Hannah Glover, Fabienne Stierli, Juanlo Catena, Melissa Carrillo, Sina Hartmann, Hans‐Peter Seidel, Matthias Mulder, Thomas Mason, Yasushi Kondo, Maximillian Wranik, Martin Appleby, Christoph Sager, Raymond Sierra, Gregory Gate, Pamela Schleissner, Xinxin Cheng, Tobias Weinert, Robert Cheng, Sandra Mous, John H. Beale, Michal Kepa, Amadeu Llebaria, Michael Hennig, Xavier Rovira, Joerg Standfuss   +29 more
wiley   +1 more source

Engineering of an artificial light-modulated potassium channel.

PLoS ONE, 2012
Ion Channel-Coupled Receptors (ICCRs) are artificial receptor-channel fusion proteins designed to couple ligand binding to channel gating. We previously validated the ICCR concept with various G protein-coupled receptors (GPCRs) fused with the inward ...
Lydia N Caro, Christophe J Moreau, Argel Estrada-Mondragón, Oliver P Ernst, Michel Vivaudou   +4 more
doaj   +1 more source

Cell‐Type‐Dependent Metabolic Compensation Preserves Photoreceptor Survival Through Pyruvate Kinase Isoform Balance

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala, Larissa J. Trevino, Tyler M. Black, Raju V. S. Rajala   +3 more
wiley   +1 more source

Expression of opsin and visual cycle-related enzymes in fetal rat skin keratinocytes and cellular response to blue light

Biochemistry and Biophysics Reports
The mechanism by which the skin, a non-visual tissue, responds to light remains unknown. To date, opsin expression has been demonstrated in keratinocytes, melanocytes, and fibroblasts, all of which are skin-derived cells.
Hiroyuki Yamamoto, Momo Okada, Yoshikazu Sawaguchi, Toshiyuki Yamada   +3 more
doaj   +1 more source

Divergence in cis-regulatory sequences surrounding the opsin gene arrays of African cichlid fishes

BMC Evolutionary Biology, 2011
Background Divergence within cis-regulatory sequences may contribute to the adaptive evolution of gene expression, but functional alleles in these regions are difficult to identify without abundant genomic resources.
Streelman J Todd, Loh Yong-Hwee E, Engel Samuel D, Schulte Jane, Naseer Zan, Smith Daniel, O'Quin Kelly E, Boore Jeffrey L, Carleton Karen L   +8 more
doaj   +1 more source

Multifunctional opsins [PDF]

Nature Reviews Neuroscience, 2020
openaire   +2 more sources

RT-qPCR reveals opsin gene upregulation associated with age and sex in guppies (Poecilia reticulata) - a species with color-based sexual selection and 11 visual-opsin genes

BMC Evolutionary Biology, 2011
Background PCR-based surveys have shown that guppies (Poecilia reticulata) have an unusually large visual-opsin gene repertoire. This has led to speculation that opsin duplication and divergence has enhanced the evolution of elaborate male coloration ...
Taylor John S, Laver Christopher RJ
doaj   +1 more source

Thermal constraints on in vivo optogenetic manipulations. [PDF]

, 2019
A key assumption of optogenetics is that light only affects opsin-expressing neurons. However, illumination invariably heats tissue, and many physiological processes are temperature-sensitive.
Kreitzer, Anatol C, Liu, Max H, Owen, Scott F   +2 more
core  

Discovery of non-retinoid compounds that suppress the pathogenic effects of misfolded rhodopsin in a mouse model of retinitis pigmentosa.

PLoS Biology
Pathogenic mutations that cause rhodopsin misfolding lead to a spectrum of currently untreatable blinding diseases collectively termed retinitis pigmentosa. Small molecules to correct rhodopsin misfolding are therefore urgently needed.
Joseph T Ortega, Jacklyn M Gallagher, Andrew G McKee, Yidan Tang, Miguel Carmena-Bargueňo, Maria Azam, Zaiddodine Pashandi, Marcin Golczak, Jens Meiler, Horacio Pérez-Sánchez, Jonathan P Schlebach, Beata Jastrzebska   +11 more
doaj   +1 more source