Results 131 to 140 of about 28,928 (224)

Discovery of non-retinoid compounds that suppress the pathogenic effects of misfolded rhodopsin in a mouse model of retinitis pigmentosa.

PLoS Biology
Pathogenic mutations that cause rhodopsin misfolding lead to a spectrum of currently untreatable blinding diseases collectively termed retinitis pigmentosa. Small molecules to correct rhodopsin misfolding are therefore urgently needed.
Joseph T Ortega, Jacklyn M Gallagher, Andrew G McKee, Yidan Tang, Miguel Carmena-Bargueňo, Maria Azam, Zaiddodine Pashandi, Marcin Golczak, Jens Meiler, Horacio Pérez-Sánchez, Jonathan P Schlebach, Beata Jastrzebska   +11 more
doaj   +1 more source

Conformational Differences among Metarhodopsin I, Metarhodopsin II, and Opsin Probed by Wide-Angle X-ray Scattering

, 2019
Among the photoproducts of vertebrate rhodopsin, only metarhodopsin II (Meta-II) preferentially adopts the active structure in which transmembrane helices are rearranged.
Yasushi Imamoto (817077), Keiichi Kojima (5228327), Yoshinori Shichida (183616), Toshihiko Oka (1327950), Ryo Maeda (529707)   +4 more
core   +1 more source

M-opsin and L-opsin expression in fetal retinas and WERI-RB-1 cells.

(A) 20 μm section of a fetal day 122 retina with expression of M-/L-opsin protein (magenta), Ki67 (cyan), and Hoechst/nuclei (white). M-/L-opsin protein is observed in the ONL. Ki67 expression indicates proliferating cells.
Michael E. G. Sauria (17775587), Thomas Reh (16248491), Sarah E. Hadyniak (17775575), Katarzyna A. Hussey (17775584), Maureen Neitz (525009), Rajiv C. McCoy (16492626), Jay Neitz (525010), James Taylor (158393), Robert J. Johnston Jr (8551161), Joanna F. D. Hagen (17775578), James A. Kuchenbecker (17775590), Ian Glass (10706557), Boris Brenerman (17775581), Kiara C. Eldred (8551155)   +13 more
core   +1 more source

OPSIN on Safari

, 2010
Very pleased to see an announcement from Chris Swain who has ported OPSIN, out chemical name2structure processor to Safari. See http://homepage.mac.com/swain/Sites/Macinchem/Extensions/opsin_extension.html <em> Opsin Extension </em> <em> The Unilever Centre for Molecular Science Informatics have been at the forefront at developing ...
openaire   +1 more source

Cichlid opsin expression plasticity qPCR data

, 2015
Cone opsin expression levels determined by qPCR relative to ...
Lu, Jessica, Leips, Jeff, Jeff Leips (363714), Thomas W. Cronin (255715), Brian E. Dalton (3320226), Cronin, Thomas W., Jessica Lu (1427524), Karen L. Carleton (255721), Dalton, Brian E., Carleton, Karen L.   +9 more
core   +1 more source

RA signaling induces M-opsin and inhibits L-opsin early in human retinal organoids.

(A–C) Expression of ALDH1A1, ALDH1A2, and ALDH1A3 in fetal human retinas by day of gestation and retinal region. CPM, log counts per million. Analyzed from [16]. Error bars for the 2 samples from fetal day 94 indicate SEM.
Michael E. G. Sauria (17775587), Thomas Reh (16248491), Sarah E. Hadyniak (17775575), Katarzyna A. Hussey (17775584), Maureen Neitz (525009), Rajiv C. McCoy (16492626), Jay Neitz (525010), James Taylor (158393), Robert J. Johnston Jr (8551161), Joanna F. D. Hagen (17775578), James A. Kuchenbecker (17775590), Ian Glass (10706557), Boris Brenerman (17775581), Kiara C. Eldred (8551155)   +13 more
core   +1 more source

Expression of M-opsin mRNA and L-opsin mRNA in fetal and adult human retinas.

(A) 20 μm sections of 122-day-old and 130-day-old human fetal retinas. M-opsin (blue) and L-opsin (pink). White arrow indicates L-opsin-expressing cell. (B) Quantification of % M and L cones in 122-day-old and 130-day-old human fetal retinas.
Michael E. G. Sauria (17775587), Thomas Reh (16248491), Sarah E. Hadyniak (17775575), Katarzyna A. Hussey (17775584), Maureen Neitz (525009), Rajiv C. McCoy (16492626), Jay Neitz (525010), James Taylor (158393), Robert J. Johnston Jr (8551161), Joanna F. D. Hagen (17775578), James A. Kuchenbecker (17775590), Ian Glass (10706557), Boris Brenerman (17775581), Kiara C. Eldred (8551155)   +13 more
core   +1 more source

Opsin sequences

All the opsin sequences used in the study (Complete, Incomplete or Pseudogene). Subfamily of each sequence can be retrieved in the csv file 'ALL_opsins_classification'
Maxime Policarpo (8596155)
core   +1 more source

Identification and Expression Patterns of Opsin Genes in <i>Phortica okadai</i>, the Only Confirmed Vector of <i>Thelazia callipaeda</i> in China. [PDF]

Insects
Jia S, Wang J, Wang L, Wang Y, Luo Y, Cao Y, Luo B, Wang L, Liu H, Zhou J.   +9 more
europepmc   +1 more source

S-Opsin Contributes to Violet Light-Dependent Refractive Development and Is Associated With Corneal Structural Remodeling in Mice. [PDF]

Invest Ophthalmol Vis Sci
Huang J, Shen Y, Duan R, Huang Y, Fang C, Shen H, Zou L, Liu H.   +7 more
europepmc   +1 more source