Results 61 to 70 of about 38,225 (233)

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

Scientific Reports, 2021
Mutations in the G protein-coupled receptor (GPCR) rhodopsin are a common cause of autosomal dominant retinitis pigmentosa, a blinding disease. Rhodopsin self-associates in the membrane, and the purified monomeric apo-protein opsin dimerizes in vitro as ...
George Khelashvili, Anoop Narayana Pillai, Joon Lee, Kalpana Pandey, Alexander M. Payne, Zarek Siegel, Michel A. Cuendet, Tylor R. Lewis, Vadim Y. Arshavsky, Johannes Broichhagen, Joshua Levitz, Anant K. Menon   +11 more
doaj   +1 more source

Evolution of opsins and phototransduction [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2009
Opsins are the universal photoreceptor molecules of all visual systems in the animal kingdom. They can change their conformation from a resting state to a signalling state upon light absorption, which activates the G protein, thereby resulting in a signalling cascade that produces physiological responses.
Yoshinori, Shichida, Take, Matsuyama
openaire   +2 more sources

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source

Opsin expression varies across larval development and taxa in pteriomorphian bivalves

Frontiers in Neuroscience
IntroductionMany marine organisms have a biphasic life cycle that transitions between a swimming larva with a more sedentary adult form. At the end of the first phase, larvae must identify suitable sites to settle and undergo a dramatic morphological ...
Md Shazid Hasan, Kyle E. McElroy, Jorge A. Audino, Jorge A. Audino, Jeanne M. Serb   +4 more
doaj   +1 more source

Novel Porcine Retina Cultivation Techniques Provide Improved Photoreceptor Preservation

Frontiers in Neuroscience, 2020
Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries among people over 60 years. It has multiple triggers and risk factors, but despite intense research efforts, its pathomechanisms are currently not ...
Natalie Wagner, Sabrina Reinehr, Maurice R. Gammel, Andrea Greulich, José Hurst, H. Burkhard Dick, Sven Schnichels, Stephanie C. Joachim   +7 more
doaj   +1 more source

Two Opsin 3-Related Proteins in the Chicken Retina and Brain: A TMT-Type Opsin 3 Is a Blue-Light Sensor in Retinal Horizontal Cells, Hypothalamus, and Cerebellum. [PDF]

PLoS ONE, 2016
Opsin family genes encode G protein-coupled seven-transmembrane proteins that bind a retinaldehyde chromophore in photoreception. Here, we sought potential as yet undescribed avian retinal photoreceptors, focusing on Opsin 3 homologs in the chicken.
Mutsuko Kato, Takashi Sugiyama, Kazumi Sakai, Takahiro Yamashita, Hirofumi Fujita, Keita Sato, Sayuri Tomonari, Yoshinori Shichida, Hideyo Ohuchi   +8 more
doaj   +1 more source

Irregular S-cone mosaics in felid retinas: spatial interaction with axonless horizontal revealed by cross-correlation [PDF]

, 2000
In most mammals short-wavelength-sensitive (S) cones are arranged in irregular patterns with widely variable intercell distances. Consequently, mosaics of connected interneurons either may show some type of correlation to photoreceptor placement or may ...
Ahnelt, Ahnelt, Ahnelt, Ahnelt, Ahnelt, Anna Kübber-Heiss, Boycott, Chan, Chiu, Clark, Cook, Curcio, Curcio, Dacey, de Monasterio, Eduardo Fernández, Famiglietti, Fernández, Gallego, Galli-Resta, Green, Hack, Hendrickson, Hokoç, Johnson, Jose Angel Bolea, Kolb, Kouyama, Long, Luo, Martin, Mills, Müller, Oscar Martinez, Peter Kurt Ahnelt, Pflug, Provencio, Raviola, Rodieck, Rodieck, Sandmann, Shapiro, Soni, Sun, Szél, Szél, Szél, Wikler, Williams, Williams, Wässle, Wässle, Wässle   +52 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source