Results 61 to 70 of about 26,493 (243)
Advanced Materials, EarlyView.We report a multifunctional tapered optical fiber integrating a conformal micro‐resistance temperature detector (µRTD) for local, real‐time thermometry during optical stimulation. The platform combines light‐delivery and temperature sensing within a minimally invasive footprint, enabling detection of sub‐degree cortical heating under representative ...
Antonio Balena +6 more
wiley +1 more source
Advanced Science, EarlyView.A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui +9 more
wiley +1 more source
Molecular insights into the eye evolution of bivalvian molluscs [PDF]
, 2006 The intention of my PhD project was to gain more insights into eye evolution and to provide further evidence for the recently proposed idea that all eye-types found in eumetazoans derive from a common Pax6-dependent proto-type eye (Gehring and Ikeo, 1999)
Keller, Lukas Emanuel
core +1 more source
PLoS ONE, 2012 Examples of direct differentiation by defined transcription factors have been provided for beta-cells, cardiomyocytes and neurons. In the human visual system, there are four kinds of photoreceptors in the retina.
Yuko Seko +8 more
doaj +1 more source
Advanced Science, EarlyView.This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina +6 more
wiley +1 more source
Adaptive Molecular Evolution in the Opsin Genes of Rapidly Speciating Cichlid Species
, 2005 Cichlid fish inhabit a diverse range of environments that vary in the spectral content of light available for vision. These differences should result in adaptive selective pressure on the genes involved in visual sensitivity, the opsin genes.
Spady, Tyrone C. +5 more
core +1 more source
Novel Porcine Retina Cultivation Techniques Provide Improved Photoreceptor Preservation
Frontiers in Neuroscience, 2020 Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries among people over 60 years. It has multiple triggers and risk factors, but despite intense research efforts, its pathomechanisms are currently not ...
Natalie Wagner +7 more
doaj +1 more source
Wild-type opsin does not aggregate with a misfolded opsin mutant
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016 Rhodopsin is the light receptor in photoreceptor cells that plays a central role in phototransduction and photoreceptor cell health. Mutations in rhodopsin are the leading cause of autosomal dominant retinitis pigmentosa (adRP), a retinal degenerative disease. A majority of mutations in rhodopsin cause misfolding and aggregation of the apoprotein opsin.
Megan, Gragg +3 more
openaire +2 more sources
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, EarlyView.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
, 2016 Expression of each opsin as a proportion of total opsin expression. (See manuscript for justification)
F. Helen Rodd (2912057) +5 more
core +1 more source