Results 121 to 130 of about 18,496 (258)
BiP prevents rod opsin aggregation
Molecular Biology of the Cell, 2012 Mutations in rod opsin—the light-sensitive protein of rod cells—cause retinitis pigmentosa. Many rod opsin mutations lead to protein misfolding, and therefore it is important to understand the role of molecular chaperones in rod opsin biogenesis. We show that BiP (HSPA5) prevents the aggregation of rod opsin.
Athanasiou, D. +7 more
openaire +3 more sources
Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors
Medicinal Research Reviews, Volume 46, Issue 2, Page 445-474, March 2026.ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara +3 more
wiley +1 more source
, 2013 The increasing interest in photoactivated proteins as natural replacement of standard inorganic materials in photocells drives to the compared analysis of bacteriorhodopsin and proteorhodopsin, two widely diffused proteins belonging to the family of ...
Alfinito, E +3 more
core +1 more source
Crustacean conundrums: a review of opsin diversity and evolution [PDF]
, 2022 Sitara Palecanda +3 more
openalex +1 more source
Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
Taking Optogenetics into the Human Brain: Opportunities and Challenges in Clinical Trial Design
Open Access Journal of Clinical Trials, 2020 Michael White,1 Michael Mackay,1 Roger G Whittaker1,2 1Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK; 2Department of Clinical Neurophysiology, Royal Victoria Hospital, Newcastle Upon Tyne NE1 4LP ...
White M, Mackay M, Whittaker RG
doaj
Evolution, inactivation and loss of short wavelength‐sensitive opsin genes during the diversification of Neotropical cichlids [PDF]
, 2021 Frances E. Hauser +5 more
openalex +1 more source
Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder
Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley +1 more source