Results 61 to 70 of about 23,776 (285)
Gene family amplification facilitates adaptation in freshwater Unionid bivalve Megalonaias nervosa [PDF]
, 2020 As organisms are faced with intense rapidly changing selective pressures, new genetic material is required to facilitate adaptation. Among sources of genetic novelty, gene duplications and transposable elements (TEs) offer new genes or new regulatory patterns that can facilitate evolutionary change.
arxiv +1 more source
Seeing the Light: The Use of Zebrafish for Optogenetic Studies of the Heart
Frontiers in Physiology, 2021 Optogenetics, involving the optical measurement and manipulation of cellular activity with genetically encoded light-sensitive proteins (“reporters” and “actuators”), is a powerful experimental technique for probing (patho-)physiological function ...
Jonathan S. Baillie +3 more
doaj +1 more source
Optogenetically Induced Spatiotemporal Gamma Oscillations in Visual Cortex [PDF]
arXiv, 2021 It has been hypothesized that Gamma cortical oscillations play important roles in numerous cognitive processes and may involve psychiatric conditions including anxiety, schizophrenia, and autism. Gamma rhythms are commonly observed in many brain regions during both waking and sleep states, yet their functions and mechanisms remain a matter of debate ...
arxiv
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor
Angewandte Chemie, EarlyView.A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth +9 more
wiley +2 more sources
Evolution of the eyes of vipers with and without infrared-sensing pit organs [PDF]
, 2019 We examined lens and brille transmittance, photoreceptors, visual pigments, and visual opsin gene sequences of viperid snakes with and without infrared-sensing pit organs. Ocular media transmittance is high in both groups.
Douglas, R. H. +12 more
core +3 more sources
Spectral Tuning of Phototaxis by a Go-Opsin in the Rhabdomeric Eyes of Platynereis [PDF]
, 2015 SummaryPhototaxis is characteristic of the pelagic larval stage of most bottom-dwelling marine invertebrates [1]. Larval phototaxis is mediated by simple eyes that can express various types of light-sensitive G-protein-coupled receptors known as opsins ...
Bezares-Calderón, Luis A. +7 more
core +1 more source
Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Color discrimination in the vertebrate retina is mediated by a combination of cone cell types expressing UV (SWS1), blue (SWS2), green (RH2), and red (LWS) opsins.
Yohey Ogawa +7 more
semanticscholar +1 more source
Unconventional Roles of Opsins.
Annual Review of Cell and Developmental Biology, 2017 Rhodopsin is the classical light sensor. Although rhodopsin has long been known to be important for image formation in the eye, the requirements for opsins in non-image formation and in extraocular light sensation were revealed much later. Most recent is
N. Leung, C. Montell
semanticscholar +1 more source
New Perspectives on Semiconducting Conjugated Oligomers for Neuromodulation in Hydra vulgaris
Advanced Materials Interfaces, EarlyView.Semiconducting organic compounds, thiophene‐based, modify the rhythmic electrical activity of the cnidarian Hydra vulgaris acting on specific neuronal circuits. The ETE‐S trimer also forms electronically conducting wires in the living tissues of the animal.
Giuseppina Tommasini +7 more
wiley +1 more source
Exploring adult hippocampal neurogenesis using optogenetics [PDF]
, 2018 In the 1980s, it was widely accepted that new neurons are continuously generated in the dentate gyrus of the mammalian hippocampus. Since its acceptance, researchers have employed various techniques and behavioral paradigms to study the proliferation ...
Pinardo, Heinrich
core