Results 61 to 70 of about 15,771 (212)
Palmitoylation stabilizes unliganded rod opsin [PDF]
Proceedings of the National Academy of Sciences, 2010 S-palmitoylation is a conserved feature in many G protein–coupled receptors (GPCRs) involved in a broad array of signaling processes. The prototypical GPCR, rhodopsin, is S-palmitoylated on two adjacent C-terminal Cys residues at its cytoplasmic surface.
Akiko, Maeda +6 more
openaire +2 more sources
Precise multimodal optical control of neural ensemble activity. [PDF]
, 2018 Understanding brain function requires technologies that can control the activity of large populations of neurons with high fidelity in space and time. We developed a multiphoton holographic approach to activate or suppress the activity of ensembles of ...
Adesnik, Hillel +8 more
core +1 more source
Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish [PDF]
, 2016 Photoreceptors are highly specialized sensory neurons that possess a modified primary cilium called the outer segment. Photoreceptor outer segment formation and maintenance require highly active protein transport via a process known as intraflagellar ...
Akhtar +44 more
core +2 more sources
TMT-Opsins differentially modulate medaka brain function in a context-dependent manner.
PLoS Biology, 2021 Vertebrate behavior is strongly influenced by light. Light receptors, encoded by functional opsin proteins, are present inside the vertebrate brain and peripheral tissues.
Bruno M Fontinha +10 more
doaj +1 more source
Exploring adult hippocampal neurogenesis using optogenetics [PDF]
, 2018 In the 1980s, it was widely accepted that new neurons are continuously generated in the dentate gyrus of the mammalian hippocampus. Since its acceptance, researchers have employed various techniques and behavioral paradigms to study the proliferation ...
Pinardo, Heinrich
core
High‐Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting
Advanced Materials, EarlyView.A DNA barcoding system enables high‐throughput in vivo screening of mitochondrial‐targeting gold nanoparticles. Thirty nanoparticle types with varied shapes, sizes, and ligands are individually barcoded and pooled. The pooled library is administered to tumor‐bearing mice, and barcodes retrieved from tumor mitochondria are amplified and sequenced to ...
Xingyue Huang +8 more
wiley +1 more source
Advanced Science, EarlyView.Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat +6 more
wiley +1 more source
The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution
eLife, 2020 Photoreceptor cells in the eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular components and physiology.
Clemens Christoph Döring +4 more
doaj +1 more source
Seeing the Light: The Use of Zebrafish for Optogenetic Studies of the Heart
Frontiers in Physiology, 2021 Optogenetics, involving the optical measurement and manipulation of cellular activity with genetically encoded light-sensitive proteins (“reporters” and “actuators”), is a powerful experimental technique for probing (patho-)physiological function ...
Jonathan S. Baillie +3 more
doaj +1 more source
Three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT). [PDF]
, 2017 Optical methods capable of manipulating neural activity with cellular resolution and millisecond precision in three dimensions will accelerate the pace of neuroscience research. Existing approaches for targeting individual neurons, however, fall short of
Adesnik, Hillel +5 more
core +2 more sources