Results 1 to 10 of about 8,266,744 (203)
Journal of Immunology Research, 2021 We recently showed that both nontypeable Haemophilus influenzae (NTHi) and its surface plasminogen- (Plg-) binding proteins interact with lipoprotein(a) (Lp(a)) in a lysine-dependent manner.
Zhi Liu +6 more
doaj +3 more sources
Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines [PDF]
Frontiers in Immunology, 2020 Understanding the effects mediated by a set of nanoparticle (NP)-bound host biomolecules, often indicated with the umbrella term of NP corona, is essential in nanomedicine, nanopharmacology, and nanotoxicology.
Emanuele Papini +4 more
doaj +3 more sources
Neutrophil Elastase and Chronic Lung Disease
Biomolecules, 2021 Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary disease, non-CF bronchiectasis, and bronchopulmonary dysplasia.
Judith A. Voynow, Meagan Shinbashi
doaj +2 more sources
PEGylated Strontium Sulfite Nanoparticles with Spontaneously Formed Surface-Embedded Protein Corona Restrict Off-Target Distribution and Accelerate Breast Tumour-Selective Delivery of siRNA [PDF]
Journal of Functional Biomaterials, 2022 As transporters of RNAi therapeutics in preclinical and clinical studies, the application of nanoparticles is often hindered by their susceptibility to opsonin-mediated clearance, poor biological stability, ineffectual targeting, and undesirable effects ...
Md. Emranul Karim +1 more
doaj +2 more sources
Bioactive Materials, 2022 A central paradigm in nanomedicine is that when synthetic nanoparticles (NPs) enter the body, they are immediately cloaked by a corona of macromolecules (mostly proteins) that mediates the role of the physico-chemical properties in the NP biological ...
Xingliang Liu +6 more
doaj +2 more sources
Protective role of Galectin-3 in prion disease through regulation of microglial PrP<sup>Sc</sup> uptake. [PDF]
Brain PatholGalectin‐3 (Gal3) is induced in reactive microglia during prion disease and promotes microglial uptake of PrPSc. Gal3 deficiency reduces prion sequestration and accelerates disease progression, revealing a protective role for Gal3. Abstract Microglia constitute a major innate defense mechanism against prion infection; however, the molecular pathways ...
Makarava N +8 more
europepmc +2 more sources
Complement evasion factor (CEF), a novel immune evasion factor of Streptococcus pyogenes
Virulence, 2022 Streptococcus pyogenes, a leading human pathogen, is responsible for a wide range of diseases, including skin and soft tissue infections and severe invasive diseases. S.
Haniyeh Aghababa +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Galectin-3 (Gal-3; formally named MAC-2) is a β-galactoside-binding lectin. Various cell types produce Gal-3 under either normal conditions and/or pathological conditions. Gal-3 can be present in cells' nuclei and cytoplasm, secreted from producing cells,
Shlomo Rotshenker
doaj +1 more source
A C1q domain containing protein from scallop Chlamys farreri serving as pattern recognition receptor with heat-aggregated IgG binding activity. [PDF]
PLoS ONE, 2012 BACKGROUND: The C1q domain containing (C1qDC) proteins refer to a family of all proteins that contain the globular C1q (gC1q) domain, and participate in a series of immune responses depending on their gC1q domains to bind a variety of self and non-self ...
Leilei Wang +5 more
doaj +1 more source
Microbes bind complement inhibitor factor H via a common site. [PDF]
PLoS Pathogens, 2013 To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
T Meri +9 more
doaj +1 more source