Results 1 to 10 of about 9,704 (180)
Microbes bind complement inhibitor factor H via a common site. [PDF]
PLoS Pathogens, 2013 To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
T Meri +9 more
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Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi. [PDF]
PLoS ONE, 2017 Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis.
Robert Kolodziejczyk +6 more
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Folia Medica Indonesiana, 2017 Escherichia coli (E. coli), a major cause of male genital tract infections, is asymptomatic and may result in male infertility. We have succeeded in isolating and characterizing proteins of E.
Sukarjati Sukarjati, Susie Amilah
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Journal of Functional Biomaterials, 2022 As transporters of RNAi therapeutics in preclinical and clinical studies, the application of nanoparticles is often hindered by their susceptibility to opsonin-mediated clearance, poor biological stability, ineffectual targeting, and undesirable effects ...
Md. Emranul Karim +1 more
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Bioactive Materials, 2022 A central paradigm in nanomedicine is that when synthetic nanoparticles (NPs) enter the body, they are immediately cloaked by a corona of macromolecules (mostly proteins) that mediates the role of the physico-chemical properties in the NP biological ...
Xingliang Liu +6 more
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Journal of Immunology Research, 2021 We recently showed that both nontypeable Haemophilus influenzae (NTHi) and its surface plasminogen- (Plg-) binding proteins interact with lipoprotein(a) (Lp(a)) in a lysine-dependent manner.
Zhi Liu +6 more
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Neutrophil Elastase and Chronic Lung Disease
Biomolecules, 2021 Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary disease, non-CF bronchiectasis, and bronchopulmonary dysplasia.
Judith A. Voynow, Meagan Shinbashi
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The human mannose-binding protein functions as an opsonin. [PDF]
The Journal of experimental medicine, 1989 The human mannose-binding protein (MBP) is a multimeric serum protein that is divided into three domains: a cysteine-rich NH2-terminal domain that stabilizes the alpha-helix of the second collagen-like domain, and a third COOH-terminal carbohydrate binding region.
M, Kuhlman, K, Joiner, R A, Ezekowitz
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An Insect Multiligand Recognition Protein Functions as an Opsonin for the Phagocytosis of Microorganisms [PDF]
Journal of Biological Chemistry, 2010 We characterize a novel pathogen recognition protein obtained from the lepidopteran Galleria mellonella. This protein recognizes Escherichia coli, Micrococcus luteus, and Candida albicans via specific binding to lipopolysaccharides, lipoteichoic acid, and beta-1,3-glucan, respectively. As a multiligand receptor capable of coping with a broad variety of
Chong Han, Kim +6 more
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Human mannose-binding protein functions as an opsonin for influenza A viruses. [PDF]
Journal of Clinical Investigation, 1993 Influenza A viruses (IAVs) cause substantial morbidity and mortality in yearly epidemics, which result from the ability of the virus to alter the antigenicity of its envelope proteins. Despite the rapid replication of this virus and its ability to infect a wide variety of cell types, viremia is rare and the infection is generally limited to the upper ...
K L, Hartshorn +6 more
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