Results 61 to 70 of about 8,266,744 (203)

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Opsonin-independent phagocytosis of activators of the alternative complement pathway by human monocytes.

Journal of Immunology, 1978
Activators of the alternative C pathway were ingested by human monocytes in a synthetic medium devoid of serum or proteins of the alternative C pathway.
J. Czop, D. Fearon, K. Austen
semanticscholar   +1 more source

Functionally and morphologically distinct populations of extracellular vesicles produced by human neutrophilic granulocytes. [PDF]

, 2018
EVs in the microvesicle size range released during spontaneous death of human neutrophils were characterized and their properties compared with previously described EVs with antibacterial effect (aEVs, generated on specific activation) or produced ...
Ligeti Erzsébet, Maria Schütte, Kenneth R. McLeish, Veres Dániel, Lőrincz Márton Ákos, Michael L. Merchant, Tímár Csaba, Kittel Ágnes   +7 more
core   +1 more source

Performance evaluation at Opsonin Pharma Limited [PDF]

, 2015
This internship report is submitted in a partial fulfillment of the requirements for the degree of Master of Business Administration, 2015.Cataloged from PDF version of Internship report.Includes bibliographical references (page 29).Opsonin Pharma ...
Zoha, Md. Samauz
core  

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function [PDF]

, 2010
Acute-phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation.
Beraza, N., Linke, Reinhold P, Dierssen, U., Magarian Blander, J., Magarian Blander, Julie, Linke, R., Müller, M.R., Sander, Leif E., Leif E. Sander, Sander, L.E., Christian Trautwein, Dierssen, Uta, Trautwein, Christian, Sara Dutton Sackett, Sander, Leif Erik, Reinhold P. Linke, Müller, Michael, Tacke, F., Dutton Sackett, Sara, Tacke, Frank, Beraza, Naiara, Blander, J Magarian, Michael Müller, Uta Dierssen, Naiara Beraza, Frank Tacke, Sackett, S.D., Sackett, Sara Dutton, Blander, J.M., Trautwein, C., Sander, Leif E, J. Magarian Blander, Linke, Reinhold P.   +32 more
core   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

The FEBS Journal, EarlyView.
C‐type lectins (CTLs) are involved in the detection of viral/microbial carbohydrates. We studied a family of soluble CTLs in the mosquito Aedes aegypti, which acts as a vector for viruses like dengue and Zika. Using crystallography, biophysics, and structure prediction approaches, we found that these proteins consistently pair together in the same ...
Mattia Bertinelli, Rupesh Balaji Jayachandran, Jack Whitehead, Cédric Leyrat, Annabel v. Clanner, Guido C Paesen, Max Renner   +6 more
wiley   +1 more source

Stealth-Engineered Albumin-Coated Nanoparticles for Targeted Therapy: Effective Drug Delivery and Tumor Suppression in Xenograft-Zebrafish Model

International Journal of Nanomedicine
Purpose In the bloodstream, nanoparticles (NPs) interact with serum proteins to form the protein corona, which includes both opsonins, promoting NP recognition and elimination, and dysopsonins, which can inhibit opsonin activity.
S. Bozzer, Maria Cristina Grimaldi, L. De Maso, Marcello Manfredi, Giuseppe Toffoli, M. Dal Bo, D. Sblattero, P. Macor   +7 more
semanticscholar   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Next Generation Smart Implant Surfaces: Engineering Multifunctional Antimicrobial, Immunomodulatory and Regenerative Interfaces

Journal of Periodontal Research, EarlyView.
Natural‐inspired nano‐textured implant surfaces can be functionalised to modulate macrophage polarisation and local immune responses. This bioactive control promotes improved tissue integration and healing outcomes. ABSTRACT Dental implants rely on a stable and functional interface between the implant surface, surrounding tissues, and the oral ...
Roberto S. Pessoa, Lauren E. Steele, Mehvish Mumtaz, Denver P. Linklater, Neil M. O'Brien‐Simpson, Vladimir Baulin, Peter Kingshott, Roy Judge, Alastair J. Sloan, Elena P. Ivanova   +9 more
wiley   +1 more source