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Clues to prognosis in anterior ischemic optic neuropathy: an optical coherence tomography angiography study. [PDF]
Int J OphthalmolRodrigo MJ +7 more
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Neurologic Clinics, 2010 Optic atrophy is a clinical term used to describe an optic disc thought to be paler than normal. Optic atrophy is not a diagnosis but an ophthalmoscopic sign. Evidence of visual loss (acuity, color vision, peripheral vision) should be present. Most optic
Karl Golnik
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Mechanistic study of optic atrophy 1 in ischemia-reperfusion disease
Journal of Molecular Medicine, 2022Mitochondria consist of the inner mitochondrial membrane and the outer mitochondrial membrane, which maintain mitochondrial homeostasis through continuous fission and fusion to ensure a healthy mitochondrial network and thus regulate normal cellular function, namely mitochondrial dynamics.
Ying Yuan, Xiao-ming Zhang
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Uncovering the relationship between optic atrophy-1 protein and mitochondria function
Physiology, 2023Mitochondria, known as the powerhouse of the cell, also participate in the regulation of ion homeostasis, redox status, cell growth and differentiation, lipid metabolism, and cell death. The inner mitochondrial membrane (IMM) plays a crucial role in the regulation of mitochondrial metabolism and function.
Xavier Chapa +3 more
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Current Opinion in Ophthalmology, 2016
Review recent advances in clinical and experimental studies of dominant optic atrophy (DOA) to better understand the complexities of pathophysiology caused by the optic atrophy 1 (OPA1) mutation.DOA is the most commonly diagnosed inherited optic atrophy, causing progressive bilateral visual loss that begins early in life.
Bo Y, Chun, Joseph F, Rizzo
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Review recent advances in clinical and experimental studies of dominant optic atrophy (DOA) to better understand the complexities of pathophysiology caused by the optic atrophy 1 (OPA1) mutation.DOA is the most commonly diagnosed inherited optic atrophy, causing progressive bilateral visual loss that begins early in life.
Bo Y, Chun, Joseph F, Rizzo
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Trans-synaptic degeneration of the optic radiation from optic nerve atrophy [PDF]
Radiology Case Reports, 2021 Fourty-seven-year-old woman with 5-year history of progressive decreased left eye vision. Optical coherence tomography showed optic nerve atrophy (left > right) and brain MRI revealed T2 hyperintense signal along the course of left optic radiations ...
Kambiz Nael +2 more
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The Role of the Optic Atrophy 1 (OPA1) Protein in Drug‐Induced Liver Injury
The FASEB Journal, 2022The liver is the metabolic hub, and is responsible for the myriad of processes including the nutrient homeostasis and detoxification. Mitochondria of liver are critical for these functions. The detoxification process in liver, when severe, often results in liver damage through causing oxidative stress.
Hakjoo Lee, Hiromi Sesaki, Yisang Yoon
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A Novel Mutation of the OPA1 Gene in a Japanese Family with Optic Atrophy Type 1
Japanese Journal of Ophthalmology, 2002To report a novel mutation of the OPA1 gene in a Japanese family with optic atrophy type 1 (OPA1) and to describe the clinical features of this family.Standard ocular examinations were performed on the proband and his two affected sons. The DNA sequence of all exons and splice sites of the OPA1 gene was determined to detect mutations.The proband and ...
Satoko, Shimizu +5 more
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Ophthalmic Genetics, 2023
Neurofibromatosis type 1 (NF1) is a multisystem disorder that primarily affects the skin and peripheral nervous system and is caused by chromosomal abnormalities and mostly truncating variants in the NF1 gene. Ocular complications such as Lisch nodules and optic pathway gliomas (OPGs) can occur in NF1 patients.
Naoko Fukunaga +5 more
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Neurofibromatosis type 1 (NF1) is a multisystem disorder that primarily affects the skin and peripheral nervous system and is caused by chromosomal abnormalities and mostly truncating variants in the NF1 gene. Ocular complications such as Lisch nodules and optic pathway gliomas (OPGs) can occur in NF1 patients.
Naoko Fukunaga +5 more
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