Results 61 to 70 of about 263,159 (256)
Advanced Science, EarlyView.Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu +14 more
wiley +1 more source
F2b11 Optic Disc Swelling from Optic Glioma
, 1972 Optic disc swelling from optic glioma. Note the signs of vein occlusion and the optociliary bypass vien at 4:00. Left eye. Anatomy: Optic disc. Pathology: Optic nerve glioma.
William F. Hoyt, MD
core
The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]
, 2011 Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
core +1 more source
Advanced Science, EarlyView.BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai +7 more
wiley +1 more source
Walsh & Hoyt: Optic Nerve Glioma
, 2005 The most common lesion that infiltrates the optic nerve is the optic glioma (1,333,334), although the most common tumors to affect the pediatric orbit are vascular ...
Nicholas J. Volpe, MD
core +1 more source
Angewandte Chemie, EarlyView.Gal‐SeNBD‐oleamide is an activatable photosensitizer (PS) with efficient uptake and selective, β‐galactosidase‐triggered activation in cancer cells, enabling efficient photodynamic ablation of glioma cells directly in brain tissue slices from mouse preclinical models and human glioblastoma patients.
Utsa Karmakar +18 more
wiley +2 more sources
F2b08 Optic Disc Swelling from Optic Glioma
, 1975 Left eye. Optic nerve glioma. Disc swelling without visual loss. Same patient as F2b_7. Anatomy: Optic disc. Pathology: Optic nerve glioma.
William F. Hoyt, MD
core
Visual prognosis of optic glioma
, 2008 BACKGROUND: Optic gliomas may unpredictably stabilize or progress. Prognosis was known to be better in patients with neurofibromatosis 1 (NF1) than those with non-NF1.
Wang, Kyu-Chang +2 more
core +1 more source
Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin b1 receptor agonist in a glioma rat model [PDF]
, 2012 Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors (B1R), inducible prototypical G-protein coupled receptors (GPCR) can regulate permeability of ...
Neugebauer Witold +47 more
core +2 more sources
Advanced Science, EarlyView.Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li +11 more
wiley +1 more source