The Present and Future of Optic Pathway Glioma Therapy [PDF]
Cells, 2023 Optic pathway gliomas (OPGs) encompass two distinct categories: benign pediatric gliomas, which are characterized by favorable prognosis, and malignant adult gliomas, which are aggressive cancers associated with a poor outcome. Our review aims to explore
Simone Dal Bello +7 more
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The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma [PDF]
Brain Sciences, 2023 Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression ...
Khushboo Irshad +6 more
doaj +4 more sources
Secondary Narcolepsy as Worsening Sign in a Pediatric Case of Optic Pathway Glioma [PDF]
Children, 2022 Narcolepsy, a neurologic disorder that leads to excessive daytime sleepiness, may represent a rare consequence of neoplastic lesions involving the sellar/parasellar and hypothalamic regions, the anatomical areas responsible for wakefulness. Optic pathway
Beatrice Laus +8 more
doaj +4 more sources
Neurosurgery for Optic Pathway Glioma: Optimizing Multidisciplinary Management [PDF]
Frontiers in Surgery, 2022 Optic pathway glioma (OPG) comprises 10% of pediatric brain tumors and 40% of all pediatric low-grade gliomas (pLGGs). While generally considered benign pathologically, many require interventions with chemotherapy, radiation, or targeted therapies ...
Derek C. Samples +4 more
doaj +2 more sources
Current update on the visual outcome of optic pathway glioma associated with neurofibromatosis type-1 [PDF]
Frontiers in Surgery, 2022 PurposeClinical and diagnostic evaluation in the follow-up of optic glioma patients with neurofibromatosis type 1 (NF-1) can be difficult. Determining whether and when to provide treatment is a significant challenge in best managing these patients ...
Janice Lasky Zeid, Janice Lasky Zeid
doaj +2 more sources
Quantitative assessment of the corneal subbasal nerve plexus in children with neurofibromatosis type 1 and optic pathway glioma using in vivo confocal microscopy [PDF]
Scientific ReportsTo quantitatively evaluate corneal subbasal nerve plexus (SNP) in children with neurofibromatosis type 1 (NF1) and optic pathway glioma using in vivo confocal microscopy (IVCM), comparing semi-automated and automated image analysis methods.
Hossein Ghahvehchian +2 more
doaj +2 more sources
NeuroImage: Clinical, 2018 Background: Radiological biomarkers which correlate with visual function are needed to improve the clinical management of optic pathway glioma (OPG) patients.
Patrick W. Hales +11 more
doaj +3 more sources
A new era for optic pathway glioma: A developmental brain tumor with life-long health consequences [PDF]
Frontiers in Pediatrics, 2023 Optic pathway and hypothalamic glioma (OPHG) are low-grade brain tumors that arise from any part of the visual pathways frequently involving the hypothalamus. The tumors grow slowly and present with features driven by their precise anatomical site, their
David A. Walker +5 more
doaj +2 more sources
Optic Pathway Glioma: Current Treatment Approaches and Ongoing Clinical Trials [PDF]
Brain SciencesOptic pathway glioma (OPG) is a rare pediatric low-grade glioma, frequently associated with neurofibromatosis type 1 (NF–1), that presents unique therapeutic challenges due to its anatomical location and its potential to impair vision, endocrine function,
Osama Elzaafarany +4 more
doaj +2 more sources
Morning glory disc anomaly and ipsilateral sporadic optic pathway glioma
American Journal of Ophthalmology Case Reports, 2018 Purpose: To present a rare case of morning glory disc anomaly in association with an ipsilateral low grade glioma. Observations: A 5 year old male presented with a unilateral morning glory disc anomaly and an ipsilateral sporadic optic pathway glioma ...
Michael Kinori +2 more
doaj +3 more sources