Results 31 to 40 of about 1,360,810 (251)

Homonymous Retinal Ganglion Cell Layer Atrophy With Asymptomatic Optic Tract Glioma in Neurofibromatosis Type I

Frontiers in Neurology, 2020
Approximately 20% of patients with Neurofibromatosis type 1 (NF1) develop optic pathway gliomas (OPGs). Not all OPGs in NF1 necessarily become vision compromising and predicting which patients might develop visual decline is difficult at present time ...
Amirah I. Momen, Ryan T. Muir, Carolina Barnett, Carolina Barnett, Arun N. E. Sundaram, Arun N. E. Sundaram   +5 more
doaj   +1 more source

The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]

, 2011
Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
core   +1 more source

Optic pathway gliomas: a review

Neurosurgical Focus, 2007
✓Optic pathway gliomas represent approximately 3–5% of childhood intracranial tumors. They usually occur in children during the first decade of life and are seen in 11–30% of patients with neurofibromatosis Type 1 (NF1). Although these tumors are typically low-grade gliomas, the clinical course and natural history are highly variable, making treatment ...
Mandy J, Binning, James K, Liu, John R W, Kestle, Douglas L, Brockmeyer, Marion L, Walker   +4 more
openaire   +2 more sources

Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? [PDF]

, 2012
BACKGROUND: CD44 has long been associated with glioma invasion while, more recently, CD155 has been implicated in playing a similar role. Notably, these two receptors have been shown closely positioned on monocytes.
James R Smith, Zaynah Maherally, Geoffrey J Pilkington, Maherally, Zaynah, Qian An, Pilkington, Geoff, An Qian, Pilkington Geoffrey J., An, Qian, Smith James R., Smith, James, Maherally Zaynah   +11 more
core   +2 more sources

Neurofibromatosis Type 1-Associated Optic Pathway Gliomas: Current Challenges and Future Prospects

Cancer Management and Research, 2023
Yunshuo Tang,1,2 David H Gutmann2 1Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO, USA; 2Department of Neurology, Washington University School of Medicine, St.
Tang Y, Gutmann DH
doaj  

Neurofibromatosis type 1-associated gliomas and other tumors: A new pathway forward?

Pediatric Hematology Oncology Journal, 2023
Neurofibromatosis type 1 (NF1) is an autosomal dominant cancer predisposition syndrome caused by germline alterations of the NF1 gene. Patients with NF1 are at increased risk for developing benign and malignant tumors, such as optic pathway glioma and ...
Andrea Webster Carrion, Amish C. Shah, Chelsea Kotch   +2 more
doaj   +1 more source

Identification of therapeutic sensitivities in a spheroid drug combination screen of Neurofibromatosis Type I associated High Grade Gliomas.

PLoS ONE, 2023
Neurofibromatosis Type 1 (NF1) patients develop an array of benign and malignant tumors, of which Malignant Peripheral Nerve Sheath Tumors (MPNST) and High Grade Gliomas (HGG) have a dismal prognosis.
Jacquelyn Dougherty, Kyra Harvey, Angela Liou, Katherine Labella, Deborah Moran, Stephanie Brosius, Thomas De Raedt   +6 more
doaj   +1 more source

Neuronal processing of behaviourally generated optic flow: experiments and model simulations [PDF]

, 2001
Kern R, Lutterklas M, Petereit C, Lindemann JP, Egelhaaf M. Neuronal processing of behaviourally generated optic flow: experiments and model simulations. Network: computation in neural systems.
Lindemann, Jens Peter ; https://orcid.org/, Petereit, Christian, Egelhaaf, Martin ; https://orcid.org/, Kern, Roland ; https://orcid.org/, Lutterklas, Maik   +4 more
core   +1 more source

Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway [PDF]

Dysregulation of Sonic hedgehog (Shh) signaling has been implicated in glioma pathogenesis. Yet, the role of this pathway in gliomagenesis remains controversial because of the lack of relevant animal models.
Ju, B., Spitsbergen, J. M., Vogel, P., Wang, Y. D., Chen, W., Wu, J., Orr, B. A., Lu, J., Jia, S., Parupalli, C., Henson, H. E., Taylor, M. R., Peters, J. L.   +12 more
core   +6 more sources

Tep1 Regulates Yki Activity in Neural Stem Cells in Drosophila Glioma Model

Frontiers in Cell and Developmental Biology, 2020
Glioblastoma Multiforme (GBM) is the most common form of malignant brain tumor with poor prognosis. Amplification of Epidermal Growth Factor Receptor (EGFR), and mutations leading to activation of Phosphatidyl-Inositol-3 Kinase (PI3K) pathway are ...
Karishma Gangwani, Kirti Snigdha, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh   +5 more
doaj   +1 more source