Results 111 to 120 of about 1,261,152 (360)

Can mammalian vision be restored following optic nerve degeneration? [PDF]

, 2016
Damien P Kuffler Institute of Neurobiology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico Abstract: For most adult vertebrates, glaucoma, trauma, and tumors close to retinal ganglion cells (RGCs) result in their neuron death and ...
Kuffler DP
core  

Robust and interpretable unit level causal inference in neural networks for pediatric myopia

npj Digital Medicine
Understanding causal mechanisms in deep learning is essential for clinical adoption, where interpretability and reliability are critical. Most existing AI systems act as black boxes, limiting transparency in medicine.
Zihui Jin, Mengtian Kang, Wuyan Zhao, Wenjin Gui, He Li, Yongfang Tu, Yongjun Huo, Canqing Yu, Weihua Song, Ningli Wang, Xu Yang, Shi-Ming Li   +11 more
doaj   +1 more source

Microscopic details of age related changes in rat optic nerve

Senses and Sciences, 2014
Background: Age-related changes in the number and density of optic nerve fibres were studied in 12-month-old (adult) and 24-month-old (aged) male Wistar rats.
Fernanda Pacella, Elena Pacella, Maria Rosaria Carbotti, Giulio De Paolis, Roberto Muscella, Carlo Cavallotti   +5 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Hemangioblastoma of the optic nerve

Human Pathology, 1994
A 43-year-old woman presented with progressive loss of vision in the right eye. Magnetic resonance imaging (MRI) showed a prominently enhancing lesion of the optic nerve, thought preoperatively to represent an optic nerve meningioma or optic neuritis. Histological examination of the excised tumor showed this lesion to be hemangioblastoma.
A, Rubio, S P, Meyers, J M, Powers, C N, Nelson, E W, de Papp   +4 more
openaire   +2 more sources

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Postural changes in optic nerve and optic nerve sheath diameters in postural orthostatic tachycardia syndrome and spontaneous intracranial hypotension: A cohort study. [PDF]

, 2019
BACKGROUND Postural orthostatic tachycardia syndrome is a disorder of the autonomic nervous system. Approximately 30% of patients experience orthostatic headaches.
Werner J Z'Graggen, Belén Rodriguez (5338697), Raya Zimmermann (7480835), Fichtner, Jens, Andreas Raabe (289411), Werner J. Z‘Graggen (7480841), Jens Fichtner, Beck, Jürgen, Debora Cipriani (7480832), Belén Rodriguez, Levin Häni (2805976), Debora Cipriani, Raya Zimmermann, Raabe, Andreas, Cipriani, Debora, Z'Graggen, Werner J., Andreas Raabe, Ulrich, Christian T., Christian T. Ulrich (7480838), Christian T Ulrich, Z’Graggen, Werner Josef, Jürgen Beck (195467), Rodriguez, Belén, Zimmermann, Raya, Levin Häni, Häni, Levin, Jens Fichtner (795231), Jürgen Beck   +27 more
core   +1 more source

Optic nerve glymphatic system: Physiological characterization, ischemia-induced changes, and neuroprotection in ischemic optic neuropathy

Neurobiology of Disease
The glymphatic system facilitates cerebrospinal fluid (CSF) circulation and metabolic waste clearance in the central nervous system. Its alterations and neuroprotective potentials in cerebral disorders also have been confirmed.
Yuning Zhang, Zidong Chen, Yufan Jiang, Qiaona Ye, Jicheng Lin, Xinyi Zhang, Deling Li, Qinyuan Hu, Yixiao Fu, Liling Liu, Yangfan Yang, Minbin Yu   +11 more
doaj   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source