Results 151 to 160 of about 14,319 (252)

Ischemic Optic Neuropathy Decompression Trial (IONDT) [PDF]

, 1993
Non-arteritic ischemic optic neuropathy (NAION), the most common cause of acute optic nerve disease in the elderly causes permanent and severe visual loss through decreased central visual acuity, peripheral visual field loss, or both. No proven treatment
Steven E. Feldon, MD, MBA
core  

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

Association of SGLT2 Inhibitor With Stroke in Type 2 Diabetes With Diabetic Retinopathy: A Multicenter Electronic Health Record Data Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5614-5626, July 2026.
ABSTRACT Aims Diabetic retinopathy (DR) is linked to elevated risks of cerebrovascular diseases. Whether sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) reduce stroke risk in patients with type 2 diabetes (T2D) and DR remains uncertain. Materials and Methods We conducted a retrospective cohort study using the TriNetX Research Network.
Kuo‐En Chen, Po‐Chun Wang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

Ischemic Optic Neuropathy: Analysis of Distribution and Etiologies in a Tertiary Care Center [PDF]

The spectrum of diseases responsible for ischemic optic neuropathies varies, yet the vast majority of these conditions stem from a relatively limited set of underlying causes.
Jimena Tatiana Hathaway; Madhura P. Shah; Drenushe Krasniqi; Joseph Rizzo III
core  

Ischemic Optic Neuropathy Following Lumbar Fusion Surgery [PDF]

, 1993
Nonarteritic ischemic optic neuropathy (na-ION) has been seen following cardiopulmonary bypass procedures, recurrent hemorrhage, therapeutic phlebotomy, bilateral radical neck dissection, intraoperative hypotension, hemodialysis and cardiac ...
David M. Katz, MD; Jonathan Trobe, MD; Wayne T. Cornblath, MD
core  

Bifidobacterium bifidum G9‐1 Intake Improves Gastrointestinal Symptoms in Type 2 Diabetes Mellitus: An Open‐Label, Randomized Controlled Trial (Binary STAR Study)

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5952-5967, July 2026.
ABSTRACT Aims To evaluate the effects of probiotics Bifidobacterium bifidum G9‐1 (BBG9‐1) on gastrointestinal symptoms in patients with Type 2 diabetes mellitus (T2DM) with diarrhoea or constipation. Materials and Methods In a 12‐week open‐label randomised controlled trial, 100 participants were randomized 1:1 to a control or BBG9‐1 group, with 12 mg ...
Genki Kobayashi, Yoshitaka Hashimoto, Tomoyuki Matsuyama, Noriyuki Kitagawa, Saori Majima, Takafumi Senmaru, Emi Ushigome, Hiroshi Okada, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui   +10 more
wiley   +1 more source

Diagnostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in Differentiating Primary From Serious Secondary Headache

European Journal of Neurology, Volume 33, Issue 7, July 2026.
In patients presenting to the emergency department with acute non‐traumatic headache, serum GFAP and neurofilament light chain were higher in serious secondary headache than in primary headache. GFAP showed stronger diagnostic performance and remained independently associated with serious secondary headache after adjustment for clinical risk factors ...
Sara‐Jessica Camerin, Cihan Atila, Claudine A. Blum, Sofia Sandgren, Aleksandra Maleska, Athina Papadopoulou, Jens Kuhle, Mira Katan, Mirjam Christ‐Crain   +8 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Improved prognosis prediction of all‐cause mortality and cardiovascular events by combined assessment of both ankle‐brachial index and brachial‐ankle pulse wave velocity in individuals with diabetes: The Kyushu prevention study for atherosclerosis, a prospective, multicenter survey

Journal of Diabetes Investigation, Volume 17, Issue 7, Page 1172-1182, July 2026.
A novel algorithm combining ABI and baPWV was developed to predict mortality and CVD risk in individuals with diabetes. This algorithm improved the accuracy of mortality and CVD risk assessment and was independent from the Framingham Risk Score. ABSTRACT Aims/Introduction People with diabetes exhibit early‐stage cardiovascular disease (CVD).
Erina Eto, Yasutaka Maeda, Noriyuki Sonoda, Hajime Nawata, Ryoichi Takayanagi, Michio Shimabukuro, Toyoshi Inoguchi   +6 more
wiley   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, Volume 604, Issue 13, Page 5170-5199, 1 July 2026.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source