Results 31 to 40 of about 10,684 (241)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

APPLICATION OF JUDD-OFELT THEORY UPON CHLOFLUOROPHOSPHATE GLASS DOPED WITH ERBIUM

Journal of Fundamental and Applied Sciences, 2015
A series of erbium doped glasses chlorofluorophosphates were prepared and characterized. The absorption spectra were analyzed to determine the Judd-Ofelt parameters. The optical performance of these doped glasses suggesting the relevance of these glasses
A. Babai, K. E. Aiadi, O. Bentouila, F. Rehoma, M. Poulain   +4 more
doaj   +1 more source

Optical Nonreciprocity in Double Optomechanical Systems with Quadratic Coupling

Photonics, 2022
In this paper, the optical nonreciprocal phenomena in double optomechanical systems with quadratic coupling are studied. Our model belongs to an optomechanical system in which three coupling modes coexist, that is, the two cavity fields are coupled with ...
Xinyu Ji, Peipei Pan, Sumei Huang, Aixi Chen   +3 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Optical Fiber Amplifiers: Optimization and PerformanceEvaluation

Diyala Journal of Engineering Sciences, 2019
This work demonstrates the simulation of two different types of optical fiber amplifiers (OFA) utilizing OptiSystem–10, namely, 3 m length of erbium doped fiber amplifier (EDFA) and 7 km length of Raman fiber amplifier (RFA).
A. k. Abass, Mohammed J. Abdul-Razak, Haneen H. Mohammed, Suad M. Kadhim, Mohammed A. Salih   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Low-Polarization, Broad-Spectrum Semiconductor Optical Amplifiers

Nanomaterials
Polarization-insensitive semiconductor optical amplifiers (SOAs) in all-optical networks can improve the signal-light quality and transmission rate. Herein, to reduce the gain sensitivity to polarization, a multi-quantum-well SOA in the 1550 nm band is ...
Meng Zhang, Tianyi Zhang, Hui Tang, Lei Liang, Yongyi Chen, Li Qin, Yue Song, Yuxin Lei, Peng Jia, Yubing Wang, Cheng Qiu, Yuntao Cao, Yongqiang Ning, Lijun Wang   +13 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

E-band telecom-compatible 40 dB gain high-power bismuth-doped fiber amplifier with record power conversion efficiency

APL Photonics
Multi-band transmission is one of the key practical solutions to cope with the continuously growing demand on the capacity of optical communication networks without changing the huge existing fiber base.
Aleksandr Donodin, Egor Manuylovich, Vladislav Dvoyrin, Mikhail Melkumov, Valery Mashinsky, Sergei Turitsyn   +5 more
doaj   +1 more source

Gain Characteristics of Hybrid Waveguide Amplifiers in SiN Photonics Integration with Er-Yb:Al₂O₃ Thin Film

Photonics
Integrated optical waveguide amplifiers, with their compact footprint, low power consumption, and scalability, are the basis for optical communications. The realization of high gain in such integrated devices is made more challenging by the tight optical
Ziming Dong, Guoqing Sun, Yuqing Zhao, Yaxin Wang, Lei Ding, Liqin Tang, Yigang Li   +6 more
doaj   +1 more source