Results 111 to 120 of about 1,570,063 (302)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Quantitative assessment and monitoring of microplastics and nanoplastics distributions and lipid metabolism in live zebrafish using hyperspectral stimulated Raman scattering microscopy

Environment International
Microplastics (MP) and nanoplastics (NP) pollutions pose a rising environmental threat to humans and other living species, given their escalating presence in essential resources that living subjects ingest and/or inhale.
Le Xin, Meizhen Huang, Zhiwei Huang
doaj   +1 more source

Design and Modeling of the Properties of the Servomechanism for a Mobile Free Space Optical Link [PDF]

, 2014
The paper deals with the design of a tracking system determined for mobile free space optical link communication system. The paper also contains description of two-step method of the optical-axes pointing process, description of the basic properties of ...
Cizmar, J., Nemecek, J.
core   +1 more source

Micro-sized tunable liquid crystal optical filters

, 2017
Liquid Crystal Arrayed Microcavities (LCAM) is a new technology for ultra-narrow optical filtering (FWHM ~ 0.1 nm) that uses pico-liter volume Fabry-Perot type optical cavities filled with liquid crystal for tuning.
Atherton, David, Barber, Zeb, Barbour, Russell, Stoltzfus, Caleb   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

CubeSpec: optical payload design

Space Telescopes and Instrumentation 2022: Optical, Infrared, and Millimeter Wave, 2022
Raskin, Gert, de Maeyer, Jeroen, Vandenbussche, Bart, Bowman, Dominic, Goris, Jan, Kempenaers, Maarten, Pember, Jacob, Royer, Pierre, Schuermans, Job, Tkachenko, Andrew, Vandepitte, Dirk, De Munter, Wim, Lanting, Jelle, Sana, Hugues   +13 more
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The concept for hard X-ray beamline optics at SLS 2.0

Journal of Synchrotron Radiation
In the scope of the latest upgrade of the Swiss Light Source, five hard X-ray beamlines will be constructed or rebuilt. To use synergies between these beamline projects, a concept is developed here for hard X-ray beamlines that is tailored to the new ...
Benedikt Roesner, Joerg Raabe, Philip R. Willmott, Uwe Flechsig   +3 more
doaj   +1 more source

Optical Design of a Miniaturized 10× Periscope Zoom Lens for Smartphones. [PDF]

Micromachines (Basel), 2023
Sun WS, Liu YH, Tien CL.
europepmc   +1 more source