Results 91 to 100 of about 11,751,807 (260)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Volume diffraction gratings for optical telecommunications applications: design study for a spectral equalizer [PDF]

, 2004
The main characteristics required for a diffraction grating used for demultiplexing functions in spectral equalizing systems are investigated, both theoretically and experimentally.
Shigapova, N.M., Massenot, S, Heggarty, Kevin, Skochilov, A.F, Loukina, Tatiana, Chevallier, Raymond, Skochilov, A, F, Loukina, T, Chevallier, R, Shigapova, N, M, Massenot, Sébastien   +10 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Implementation of FORMIDABLE: A generalized differential optical design library with NURBS capabilities

Journal of the European Optical Society-Rapid Publications
In this article we describe the implementation of Freeform Optics Raytracer with Manufacturable Imaging Design cApaBiLitiEs (FORMIDABLE): an optical design library capable of simulating optical systems by ray-tracing.
Volatier Jean-Baptiste, Beaussier Stephane J., Druart Guillaume, Jougla Paul, Keller Fanny   +4 more
doaj   +1 more source

Numerical simulations of beam propagation through optical turbulence for high-altitude platform crosslinks [PDF]

, 2004
In this paper we introduce a simulation method for modelling clear-air atmospheric turbulence effects for long horizontal stratospheric paths. Divergence angles of several hundred microradians in combination with link distances up to 800 km require to ...
Perlot, Nicolas, Jüngling, Ralf, Giggenbach, Dirk, Horwath, Joachim   +3 more
core  

Tacit Learning in an Extended Interior Design Studio [PDF]

, 2019
5th DRS Learn X Design International Conference for Design Education Researchers: Insider Knowledge, 9-12 July 2019, METU, Ankara202403 bckwVersion of RecordSelf ...
Venkatesh, A, Ma, H, Henry Ma, Venkatesh, Aruna, Aruna Venkatesh, Ma, Henry   +5 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Design of a Society of Automotive Engineers Regular Curved Retroreflector for Enhancing Optical Efficiency and Working Area

Crystals, 2018
A highly efficient regular curved retroreflector is proposed to meet the requirements of the US Society of Automotive Engineers (SAE) regulations. It is demonstrated that 28% higher retroreflection efficiency and 33% more working area can be accomplished
Lanh-Thanh Le, Hien-Thanh Le, Jetter Lee, Hsin-Yi Ma, Hsiao-Yi Lee   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source