Results 51 to 60 of about 666,055 (319)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Ultra-Wide-Field Long-Wave Infrared System via Hybrid Refractive–Reflective Structure and Field of View Stitching

open access: yesPhotonics
To address the application demands of ultra-wide-field optical systems, we developed a compact, long-infrared waveband optical system using a field-of-view (FoV) stitching method.
Yiruo Wang, Shan Mao, Jianlin Zhao
doaj   +1 more source

Design Study of a Large-Angle Optical Scanning System for MEMS LIDAR

open access: yesApplied Sciences, 2022
MEMS-based LIDAR has the advantages of fast-scanning, simple structure, small volume, and light weight, which make it a hot topic for 3D imaging. In order to overcome the limited scanning angle of the current MEMS mirrors, a large angle MEMS-based ...
Yajun Pang   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

An Analysis and Optimization of Distortion Effect Caused by Pupil Decentering in Optical Gun Scope

open access: yesPhotonics
During the use of optical gun scopes, slight movements between the human eye and the instrument can cause the pupil to offset from the optical axis, resulting in a dynamic distortion effect. This affects the accuracy and stability of aiming. Based on the
Kaiyu Yang   +4 more
doaj   +1 more source

Optical Design of a Quantitative Microvolume Nucleic Acid Spectrophotometer with Non-Optical Fiber and All Radiation-Hardened Lens Elements

open access: yesPhotonics, 2021
The purity of the nucleic acid samples obtained by extraction/precipitation or adsorption chromatography must be verified with microvolume spectrophotometry to ensure a high success rate of the subsequent nucleic acid sequencing while exploring the trace
Sheng-Feng Lin
doaj   +1 more source

Computer-generated diffractive optical elements for optical interconnections: design and validation codes

open access: yes, 1994
In this paper we discuss the design of Diffractive Optical Elements that can be used for optical interconnections. Quite general computer programs have been realized for the design and the validation of such optical elements. As examples, in the paper we
Ivo Montrosset   +4 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Active Optics–Freeform Segment Mirror Replications from a Deformable Matrix

open access: yesPhotonics, 2022
We present a new active optics method for making smooth aspheric, or freeform, mirrors by replication technique from an elastically deformable matrix.
Gerard R. Lemaitre, Patrick Lanzoni
doaj   +1 more source

The Design of Optical Routes Applications [PDF]

open access: yes, 2007
Contemporary optical fibers can deal with almost all of the unfavorable effects which are known these days. They have sufficiently low specific slump, they can handle a slump caused by OH-ions, they can restrain the multimode effect and finally they can compensate a chromatic dispersion.
Martin Kyselak, Miloslav Filka
openaire   +1 more source

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