Results 181 to 190 of about 99,235 (279)

Optical genome mapping as a diagnostic tool for unsolved balanced translocations in couples with adverse pregnancy outcomes: a case series. [PDF]

Eur J Med Res
Zhang X, Liao Y, Cao L, Lin H, Wu X, Liao L, Tan C, Ma S, Huang G.   +8 more
europepmc   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Diagnostic Utility of Optical Genome Mapping in X-Linked Dominant Genodermatoses: Incontinentia Pigmenti and CHILD Syndrome. [PDF]

Mol Syndromol
Vergara A, Monge I, Garoz BF, Ruiz S, Alonso M, Torrelo A, Ortiz Cabrera NV.   +6 more
europepmc   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

TelOMpy enables single-molecule resolution of telomere length from optical genome mapping data. [PDF]

BMC Biol
Pokrovac I, Stipoljev S, Pezer Ž.
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

P573: Genome-wide short tandem repeat expansion screening using optical genome mapping*

Genetics in Medicine Open
James Yu, Mike Gallagher, Shuk Shukor, Alex Hastie, Alka Chaubey   +4 more
doaj   +1 more source

Optical genome mapping in myelofibrosis: enhancing prognostic accuracy through high-resolution genomic profiling. [PDF]

Blood Adv
Díaz-González Á, Mora E, Garrote M, Carreño-Tarragona G, Salido M, Pastor-Galán I, Stuckey R, Cisneros A, Domingo-Monfort JA, Uresandi-Iruin N, Argoitia-Ituarte N, Avetisyan G, García-Ruiz C, Torres-Hernández N, Furió S, Arellano-Rodrigo E, Álvarez N, Vélez P, Villamón E, Segura-Díaz A, Ayala R, Espinet B, Álvarez-Larrán A, Hernández-Boluda JC, Such E.   +24 more
europepmc   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Pilot evaluation of optical genome mapping in chronic lymphocytic leukemia: complementing FISH analysis. [PDF]

BMC Cancer
Erdem S, Bayrak Tokaç AG, Aday A, Karaca D, Mutlu MB, Çefle K, Yenerel MN, Öztürk Ş, Kalayoğlu Beşışık S.   +8 more
europepmc   +1 more source