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A comprehensive framework for evaluation of high pacing frequency and arrhythmic optical mapping signals [PDF]
Frontiers in Physiology, 2023 Introduction: High pacing frequency or irregular activity due to arrhythmia produces complex optical mapping signals and challenges for processing.
Girish S. Ramlugun +16 more
doaj +2 more sources
Advances in optical mapping for genomic research
Computational and Structural Biotechnology Journal, 2020 Recent advances in optical mapping have allowed the construction of improved genome assemblies with greater contiguity. Optical mapping also enables genome comparison and identification of large-scale structural variations.
Yuxuan Yuan +2 more
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A fully-automated low-cost cardiac monolayer optical mapping robot [PDF]
Frontiers in Cardiovascular Medicine, 2023 Scalable and high-throughput electrophysiological measurement systems are necessary to accelerate the elucidation of cardiac diseases in drug development.
Peter Lee +15 more
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Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells [PDF]
Cells, 2023 Mohammed Djemai +2 more
exaly +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Activation during onset of atrial fibrillation is poorly understood. We aimed at developing a panoramic optical mapping system for the atria and test the hypothesis that sequential rotors underlie acceleration of atrial fibrillation during ...
Óscar Salvador‐Montañés +11 more
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Structural Refinement by Direct Mapping Reveals Assembly Inconsistencies near Hi-C Junctions
Plants, 2023 High-throughput chromosome conformation capture (Hi-C) is widely used for scaffolding in de novo assembly because it produces highly contiguous genomes, but its indirect statistical approach can introduce connection errors.
Luca Marcolungo +10 more
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Frontiers in Physiology, 2023 Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes muscle weakness and myotonia. In DM1 patients, cardiac electrical manifestations include conduction defects and atrial fibrillation.
Marion Pierre +9 more
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Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks
Frontiers in Physiology, 2021 The analysis of electrical impulse phenomena in cardiac muscle tissue is important for the diagnosis of heart rhythm disorders and other cardiac pathophysiology. Cardiac mapping techniques acquire local temporal measurements and combine them to visualize
Jan Lebert +4 more
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Integration of Engineered “Spark-Cell” Spheroids for Optical Pacing of Cardiac Tissue
Frontiers in Bioengineering and Biotechnology, 2021 Optogenetic methods for pacing of cardiac tissue can be realized by direct genetic modification of the cardiomyocytes to express light-sensitive actuators, such as channelrhodopsin-2, ChR2, or by introduction of light-sensitized non-myocytes that couple ...
Christianne J. Chua +4 more
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Frontiers in Physiology, 2021 BackgroundClinical experience showed that the majority of Torsade de Pointes (TdP) ventricular tachyarrhythmia (VT) in patients with long QT syndrome (LQTS) are self-terminating (ST), but the few that are non-self-terminating (NST) are potentially fatal.
Herman D. Himel +7 more
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