Results 21 to 30 of about 152,381 (261)
Frontiers in Physiology, 2013 Alternans of action potential duration has been associated with T-wave alternans and the development of arrhythmias because it produces large gradients of repolarization. However, little is known about alternans dynamics in large mammalian hearts.
Alessio eGizzi +5 more
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Optogenetic Control of Human Induced Pluripotent Stem Cell‐Derived Cardiac Tissue Models
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Optogenetics, using light‐sensitive proteins, emerged as a unique experimental paradigm to modulate cardiac excitability. We aimed to develop high‐resolution optogenetic approaches to modulate electrical activity in 2‐ and 3‐dimensional ...
Amit Gruber +8 more
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Refinement of optical map assemblies [PDF]
Bioinformatics, 2006 Abstract Motivation: Genomic mutations and variations provide insightful information about the functionality of sequence elements and their association with human diseases. Traditionally, variations are identified through analysis of short DNA sequences, usually shorter than 1000 bp per fragment. Optical maps provide both faster and more
Anton Valouev +3 more
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Optical Mapping of Cardiac Electromechanics [PDF]
Biophysical Journal, 2016 Cardiac biophysics rests on three fundamental pillars: energy production, electrical excitation, and mechanical work. Studies of cardiac metabolism, bioelectricity, and biomechanics have been very productive at all levels of reduced complexity, but especially at the levels of tissue, cell, and molecule.
Matthew W, Kay, Igor R, Efimov
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Frontiers in Physiology, 2019 IntroductionThe upstroke of optical action potentials (APs) recorded from intact hearts are generally recognized to be slower than those recorded with microelectrodes.
Christopher O’Shea +4 more
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Frontiers in Physiology, 2014 Light scattering during optical imaging of electrical activation within the heart is known to significantlydistort the optically-recorded action potential (AP) upstroke, as well as affecting the magnitude of the measured response of ventricular tissue to
Martin J Bishop, Gernot ePlank
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Probing the Electrophysiology of the Developing Heart
Journal of Cardiovascular Development and Disease, 2016 Many diseases that result in dysfunction and dysmorphology of the heart originate in the embryo. However, the embryonic heart presents a challenging subject for study: especially challenging is its electrophysiology.
Michiko Watanabe +5 more
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Error correcting optical mapping data [PDF]
GigaScience, 2018 Abstract Optical mapping is a unique system that is capable of producing high-resolution, high-throughput genomic map data that gives information about the structure of a genome . Recently it has been used for scaffolding contigs and for assembly validation for large-scale sequencing projects, including the maize, goat, and Amborella ...
Kingshuk Mukherjee +4 more
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OMSim: a simulator for optical map data [PDF]
Bioinformatics, 2017 Abstract Motivation The Bionano Genomics platform allows for the optical detection of short sequence patterns in very long DNA molecules (up to 2.5 Mbp). Molecules with overlapping patterns can be assembled to generate a consensus optical map of the entire genome.
Giles Miclotte +5 more
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Applications of Optical DNA Mapping in Microbiology [PDF]
BioTechniques, 2017 Optical mapping (OM) has been used in microbiology for the past 20 years, initially as a technique to facilitate DNA sequence-based studies; however, with decreases in DNA sequencing costs and increases in sequence output from automated sequencing platforms, OM has grown into an important auxiliary tool for genome assembly and comparison.
Bogas, Diana +10 more
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