Results 31 to 40 of about 152,381 (261)
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingPlatform jitter is a common phenomenon of high-resolution optical satellites, which severely degrades the imaging quality both in geometric and radiometric aspects, particularly for time delay and integration (TDI) imagery with submeter ground sample ...
Ying Zhu +4 more
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Optical mapping of release properties in synapses [PDF]
Frontiers in Neural Circuits, 2010 Synapses are important functional units that determine how information flows through the brain. Understanding their biophysical properties and the molecules that underpin them is an important goal of cellular neuroscience. Thus, it is of interest to develop protocols that allow easy measurement of synaptic parameters in model systems that permit ...
Pablo Ariel, Pablo Ariel, Timothy A Ryan
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Statistical Significance of Optical Map Alignments [PDF]
Journal of Computational Biology, 2012 Abstract The Optical Mapping System constructs ordered restriction maps spanning entire genomes through the assembly and analysis of large datasets comprising individually analyzed genomic DNA molecules. Such restriction maps uniquely reveal mammalian genome structure and variation, but also raise computational and statistical ...
Deepayan Sarkar +3 more
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Physiological Reports, 2022 Ectopic activation during early acute regional ischemia may initiate fatal reentrant arrhythmias. However, the origin of this ectopy remains poorly understood.
Hanyu Zhang +3 more
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Frontiers in Physiology, 2022 Most cardiac arrhythmias at the whole heart level result from alteration of cell membrane ionic channels and intracellular calcium concentration ([Ca2+]i) cycling with emerging spatiotemporal behavior through tissue-level coupling.
Ilija Uzelac +7 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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Frontiers in Physiology, 2021 Sarcoplasmic reticulum (SR) Ca2+ cycling is tightly regulated by ryanodine receptor (RyR) Ca2+ release and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) Ca2+ uptake during each excitation–contraction coupling cycle.
Lianguo Wang +4 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundCardiac arrhythmias are common causes of death in patients with myotonic dystrophy (dystrophia myotonica [DM]). Evidence shows that atrial tachyarrhythmia is an independent risk factor for sudden death; however, the relationship is unclear ...
Chung‐Chuan Chou +3 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source