Results 41 to 50 of about 152,698 (262)

Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease

Journal of Cardiovascular Development and Disease, 2018
The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac ...
Catherine E. Lipovsky, Brittany D. Brumback, Aditi Khandekar, Stacey L. Rentschler   +3 more
doaj   +1 more source

Cardiac Optical Mapping in Situ in Swine Models: A View of the Current Situation

Medicina, 2020
Optical mapping is recognized as a promising tool for the registration of electrical activity in the heart. Most cardiac optical mapping experiments are performed in ex vivo isolated heart models. However, the electrophysiological properties of the heart
Irma Martišienė, Regina Mačianskienė, Rimantas Benetis, Jonas Jurevičius   +3 more
doaj   +1 more source

Circle Method for Robust Estimation of Local Conduction Velocity High-Density Maps From Optical Mapping Data: Characterization of Radiofrequency Ablation Sites

Frontiers in Physiology, 2022
Conduction velocity (CV) slowing is associated with atrial fibrillation (AF) and reentrant ventricular tachycardia (VT). Clinical electroanatomical mapping systems used to localize AF or VT sources as ablation targets remain limited by the number of ...
Jimena G. Siles-Paredes, Jimena G. Siles-Paredes, Christopher J. Crowley, Flavio H. Fenton, Neal Bhatia, Shahriar Iravanian, Italo Sandoval, Stefan Pollnow, Olaf Dössel, João Salinet, João Salinet, Ilija Uzelac   +11 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Capturing structure and function in an embryonic heart with Biophotonic tools

Frontiers in Physiology, 2014
Disturbed cardiac function (flow, excitation, contraction, calcium transients) at an early stage of development has been shown to correlate with and may lead to cellular/molecular, functional and structural cardiac anomalies at later stages culminating ...
Ganga eKarunamuni, Shi eGu, Lindsy M Peterson, Pei eMa, Yves T Wang, Yves T Wang, Andrew M Rollins, Michael W Jenkins, Michael W Jenkins, Michiko eWatanabe   +9 more
doaj   +1 more source

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

Biomolecules, 2020
Elsholtzia ciliata essential oil (E. ciliata) has been developed in Lithuania and internationally patented as exerting antiarrhythmic properties. Here we demonstrate the pharmacological effects of this herbal preparation on cardiac electrical activity ...
Regina Mačianskienė, Lauryna Pudžiuvelytė, Jurga Bernatonienė, Mantė Almanaitytė, Antanas Navalinskas, Rimantas Treinys, Inga Andriulė, Jonas Jurevičius   +7 more
doaj   +1 more source

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Advances in optical mapping for genomic research

Computational and Structural Biotechnology Journal, 2020
Recent advances in optical mapping have allowed the construction of improved genome assemblies with greater contiguity. Optical mapping also enables genome comparison and identification of large-scale structural variations.
Yuxuan Yuan, Claire Yik-Lok Chung, Ting-Fung Chan   +2 more
doaj   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Optical Electrophysiology in the Developing Heart

Journal of Cardiovascular Development and Disease, 2018
The heart is the first organ system to form in the embryo. Over the course of development, cardiomyocytes with differing morphogenetic, molecular, and physiological characteristics are specified and differentiate and integrate with one another to ...
Kandace Thomas, Julie Goudy, Trevor Henley, Michael Bressan   +3 more
doaj   +1 more source