Results 41 to 50 of about 152,381 (261)

Optical Imaging of Ventricular Action Potentials in a Torso Tank: A New Platform for Non-Invasive Electrocardiographic Imaging Validation

Frontiers in Physiology, 2019
Background: Non-invasive electrocardiographic imaging (ECGI) is a promising tool to provide high-resolution panoramic imaging of cardiac electrical activity noninvasively from body surface potential measurements.
Laura R. Bear, Laura R. Bear, Laura R. Bear, Richard D. Walton, Richard D. Walton, Richard D. Walton, Emma Abell, Emma Abell, Emma Abell, Yves Coudière, Yves Coudière, Yves Coudière, Yves Coudière, Michel Haissaguerre, Michel Haissaguerre, Michel Haissaguerre, Michel Haissaguerre, Olivier Bernus, Olivier Bernus, Olivier Bernus, Rémi Dubois, Rémi Dubois, Rémi Dubois   +22 more
doaj   +1 more source

Circle Method for Robust Estimation of Local Conduction Velocity High-Density Maps From Optical Mapping Data: Characterization of Radiofrequency Ablation Sites

Frontiers in Physiology, 2022
Conduction velocity (CV) slowing is associated with atrial fibrillation (AF) and reentrant ventricular tachycardia (VT). Clinical electroanatomical mapping systems used to localize AF or VT sources as ablation targets remain limited by the number of ...
Jimena G. Siles-Paredes, Jimena G. Siles-Paredes, Christopher J. Crowley, Flavio H. Fenton, Neal Bhatia, Shahriar Iravanian, Italo Sandoval, Stefan Pollnow, Olaf Dössel, João Salinet, João Salinet, Ilija Uzelac   +11 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease

Journal of Cardiovascular Development and Disease, 2018
The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac ...
Catherine E. Lipovsky, Brittany D. Brumback, Aditi Khandekar, Stacey L. Rentschler   +3 more
doaj   +1 more source

Cardiac Optical Mapping in Situ in Swine Models: A View of the Current Situation

Medicina, 2020
Optical mapping is recognized as a promising tool for the registration of electrical activity in the heart. Most cardiac optical mapping experiments are performed in ex vivo isolated heart models. However, the electrophysiological properties of the heart
Irma Martišienė, Regina Mačianskienė, Rimantas Benetis, Jonas Jurevičius   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Capturing structure and function in an embryonic heart with Biophotonic tools

Frontiers in Physiology, 2014
Disturbed cardiac function (flow, excitation, contraction, calcium transients) at an early stage of development has been shown to correlate with and may lead to cellular/molecular, functional and structural cardiac anomalies at later stages culminating ...
Ganga eKarunamuni, Shi eGu, Lindsy M Peterson, Pei eMa, Yves T Wang, Yves T Wang, Andrew M Rollins, Michael W Jenkins, Michael W Jenkins, Michiko eWatanabe   +9 more
doaj   +1 more source

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

Biomolecules, 2020
Elsholtzia ciliata essential oil (E. ciliata) has been developed in Lithuania and internationally patented as exerting antiarrhythmic properties. Here we demonstrate the pharmacological effects of this herbal preparation on cardiac electrical activity ...
Regina Mačianskienė, Lauryna Pudžiuvelytė, Jurga Bernatonienė, Mantė Almanaitytė, Antanas Navalinskas, Rimantas Treinys, Inga Andriulė, Jonas Jurevičius   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

EP-PINNs: Cardiac Electrophysiology Characterisation Using Physics-Informed Neural Networks

Frontiers in Cardiovascular Medicine, 2022
Accurately inferring underlying electrophysiological (EP) tissue properties from action potential recordings is expected to be clinically useful in the diagnosis and treatment of arrhythmias such as atrial fibrillation.
Clara Herrero Martin, Clara Herrero Martin, Alon Oved, Rasheda A. Chowdhury, Elisabeth Ullmann, Nicholas S. Peters, Anil A. Bharath, Marta Varela   +7 more
doaj   +1 more source