Results 251 to 260 of about 184,715 (310)

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Enhanced resolution of optical genome mapping utilizing telomere-to-telomere reference in genetic disorders. [PDF]

Eur J Hum Genet
Banu S, Mk K, George JK, Siby E, Bhagat R, Ms S, Patil SJ, Phadke SR, Sowpati DT, Tallapaka KB.   +9 more
europepmc   +1 more source

Optical genome mapping: Unraveling complex variations and enabling precise diagnosis in dystrophinopathy. [PDF]

Ann Clin Transl Neurol
Mai J, Duan J, Chen X, Liu L, Liang D, Fu T, Lu G, Chan WY, Luo X, Wen F, Liao J, Li Z, Lu X.   +12 more
europepmc   +1 more source

Optical Genome Mapping for Detection of BCR::ABL1-Another Tool in Our Toolbox. [PDF]

Genes (Basel)
Tang Z, Wang W, Toruner GA, Hu S, Fang H, Xu J, You MJ, Medeiros LJ, Khoury JD, Tang G.   +9 more
europepmc   +1 more source

Value of Optical Genome Mapping (OGM) for Diagnostics of Rare Diseases: A Family Case Report. [PDF]

Balkan J Med Genet
Kovanda A, Miljanović O, Lovrečić L, Maver A, Hodžić A, Peterlin B.   +5 more
europepmc   +1 more source

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Optical Genome Mapping for Oncology Applications

Current Protocols, 2023
AbstractOptical genome mapping (OGM) is a next‐generation cytogenomic technology that has the potential to replace standard‐of‐care technologies used in the genetic workup of various malignancies. The ability to detect various classes of structural variations that include copy number variations, deletions, duplications, balanced and unbalanced events ...
Nikhil Shri, Sahajpal, Ashis K, Mondal, Alex, Hastie, Alka, Chaubey, Ravindra, Kolhe   +4 more
openaire   +2 more sources

Genomics via Optical Mapping II: Ordered Restriction Maps

Journal of Computational Biology, 1997
In this paper, we describe our algorithmic approach to constructing ordered restriction maps based on the data created from the images of population of individual DNA molecules (clones) digested by restriction enzymes. The goal is to devise map-making algorithms capable of producing high-resolution, high-accuracy maps rapidly and in a scalable manner ...
T S, Anantharaman, B, Mishra, D C, Schwartz   +2 more
openaire   +2 more sources

Integration of Optical Genome Mapping in the Cytogenomic and Molecular Work‐Up of Hematological Malignancies: Expert Recommendations From the International Consortium for Optical Genome Mapping

American journal of hematology/oncology
The latest updates to the classification of hematolymphoid malignancies using the World Health Organization (WHO, 5th ed.) and ICC (International Consensus Classification) criteria highlight the critical need for comprehensive and precise cytogenomic ...
R. Kanagal-Shamanna, A. Puiggros, Isabel Granada, G. Raca, Katrina Rack, M. Mallo, Barbara Dewaele, Adam C Smith, Y. Akkari, Brynn Levy, Robert P. Hasserjian, Adela Cisneros, M. Salido, G. Garcia-Manero, Hui Yang, M. A. Iqbal, R. Kolhe, Francesc Solé, B. Espinet   +18 more
semanticscholar   +1 more source