Results 71 to 80 of about 343,154 (297)
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Manipulation and assembly of nanowires with holographic optical traps
, 2005 We demonstrate that semiconductor nanowires measuring just a few nanometers in diameter can be translated, rotated, cut, fused and organized into nontrivial structures using holographic optical traps.
Agarwal, Ritesh +5 more
core +1 more source
Orientation of biological cells using plane-polarized Gaussian beam optical tweezers [PDF]
, 2003 Optical tweezers are widely used for the manipulation of cells and their internal structures. However, the degree of manipulation possible is limited by poor control over the orientation of trapped cells. We show that it is possible to controllably align
Bayoudh, S. +3 more
core +2 more sources
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Design, Analysis, and Manufacturing of Diffractive Achromatic Optical Systems
MicromachinesThe increasing resolution requirements of imaging optical systems must be satisfied by expanding the aperture of the optical system according to Rayleigh’s criterion, and larger apertures of conventional refractive/reflective optics place a greater ...
Yidi Zheng +5 more
doaj +1 more source
An integrated processor for photonic quantum states using a broadband light-matter interface
, 2014 Faithful storage and coherent manipulation of quantum optical pulses are key for long distance quantum communications and quantum computing. Combining these functions in a light-matter interface that can be integrated on-chip with other photonic quantum ...
Heshami, Khabat +5 more
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Free-form catenary-inspired meta-couplers for ultra-high or broadband vertical coupling
NanophotonicsMetasurface-assisted waveguide couplers, or meta-couplers, innovatively link free-space optics with on-chip devices, offering flexibility for polarization and wavelength (de)multiplexing, mode-selective coupling, and guided mode manipulation.
Chen Tianqu +11 more
doaj +1 more source
MicromachinesMask optimization is a critical technique for enhancing imaging performance in digital micromirror device (DMD)-based maskless lithography. Conventional algorithms, however, often suffer from slow convergence and limited adaptability, particularly when ...
Zhiyong Chen +5 more
doaj +1 more source