Results 21 to 30 of about 4,290,469 (326)

Cardiac involvement in patient-specific induced pluripotent stem cells of myotonic dystrophy type 1: unveiling the impact of voltage-gated sodium channels

Frontiers in Physiology, 2023
Myotonic dystrophy type 1 (DM1) is a genetic disorder that causes muscle weakness and myotonia. In DM1 patients, cardiac electrical manifestations include conduction defects and atrial fibrillation.
Marion Pierre, Mohammed Djemai, Charles-Albert Chapotte-Baldacci, Valérie Pouliot, Jack Puymirat, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Chahine, Mohamed Chahine   +9 more
doaj   +1 more source

Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks

Frontiers in Physiology, 2021
The analysis of electrical impulse phenomena in cardiac muscle tissue is important for the diagnosis of heart rhythm disorders and other cardiac pathophysiology. Cardiac mapping techniques acquire local temporal measurements and combine them to visualize
Jan Lebert, Namita Ravi, Namita Ravi, Flavio H. Fenton, Jan Christoph   +4 more
doaj   +1 more source

Whole-genome optical mapping of bone-marrow myeloma cells reveals association of extramedullary multiple myeloma with chromosome 1 abnormalities

Scientific Reports, 2021
Extramedullary disease (EMM) represents a rare, aggressive and mostly resistant phenotype of multiple myeloma (MM). EMM is frequently associated with high-risk cytogenetics, but their complex genomic architecture is largely unexplored.
E. Kriegová, R. Fillerova, J. Minařík, J. Savara, J. Manakova, A. Petrackova, Martin Dihel, J. Balcárková, P. Krhovská, T. Pika, P. Gajdos, M. Behálek, M. Vašinek, T. Papajík   +13 more
semanticscholar   +1 more source

Integration of Engineered “Spark-Cell” Spheroids for Optical Pacing of Cardiac Tissue

Frontiers in Bioengineering and Biotechnology, 2021
Optogenetic methods for pacing of cardiac tissue can be realized by direct genetic modification of the cardiomyocytes to express light-sensitive actuators, such as channelrhodopsin-2, ChR2, or by introduction of light-sensitized non-myocytes that couple ...
Christianne J. Chua, Julie L. Han, Weizhen Li, Wei Liu, Emilia Entcheva   +4 more
doaj   +1 more source

Simultaneous triple-parametric optical mapping of transmembrane potential, intracellular calcium and NADH for cardiac physiology assessment

Communications Biology, 2021
Investigation of the complex relationships and dependencies of multiple cellular processes that govern cardiac physiology and pathophysiology requires simultaneous dynamic assessment of multiple parameters.
Sharon A. George, Zexu Lin, I. Efimov
semanticscholar   +1 more source

Single-molecule optical mapping of the distribution of DNA phosphorothioate epigenetics

Nucleic Acids Research, 2021
DNA phosphorothioate (PT) modifications, with the nonbridging phosphate oxygen replaced by sulfur, governed by DndABCDE or SspABCD, are widely distributed in prokaryotes and have a highly unusual feature of occupying only a small portion of available ...
Yue Wei, Qinqin Huang, Xihao Tian, Mingmin Zhang, Junkai He, Xingxiang Chen, Chao Chen, Z. Deng, Zhiqiang Li, Shi Chen, Lianrong Wang   +10 more
semanticscholar   +1 more source

Voltage/Calcium Uncoupling Underlies Sustained Torsade de Pointes Ventricular Tachyarrhythmia in an Experimental Model of Long QT Syndrome

Frontiers in Physiology, 2021
BackgroundClinical experience showed that the majority of Torsade de Pointes (TdP) ventricular tachyarrhythmia (VT) in patients with long QT syndrome (LQTS) are self-terminating (ST), but the few that are non-self-terminating (NST) are potentially fatal.
Herman D. Himel, Michael Cupelli, Michael Cupelli, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir, Nabil El-Sherif, Nabil El-Sherif   +7 more
doaj   +1 more source

Effect of Amiodarone and Hypothermia on Arrhythmia Substrates During Resuscitation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Amiodarone is administered during resuscitation, but its antiarrhythmic effects during targeted temperature management are unknown. The purpose of this study was to determine the effect of both therapeutic hypothermia and amiodarone on ...
Joseph S. Piktel, Yi Suen, Shalen Kouk, Danielle Maleski, Gary Pawlowski, Kenneth R. Laurita, Lance D. Wilson   +6 more
doaj   +1 more source

Object Tracking in Satellite Videos Based on Correlation Filter with Multi-Feature Fusion and Motion Trajectory Compensation

Remote Sensing, 2022
As a new type of earth observation satellite approach, video satellites can continuously monitor an area of the Earth and acquire dynamic and abundant information by utilizing video imaging.
Yaosheng Liu, Yurong Liao, Cunbao Lin, Yutong Jia, Zhaoming Li, Xinyan Yang   +5 more
doaj   +1 more source

Signal-based optical map alignment [PDF]

PLOS ONE, 2021
AbstractIn genomics, optical mapping technology provides long-range contiguity information to improve genome sequence assemblies and detect structural variation. Originally a laborious manual process, Bionano Genomics platforms now offer high-throughput, automated optical mapping based on chips packed with nanochannels through which unwound DNA is ...
Akdel, Mehmet, Van De Geest, Henri, Schijlen, Elio, Van Rijswijck, Irma M.H., Smid, Eddy J., Sanchez-Perez, Gabino, De Ridder, Dick   +6 more
openaire   +4 more sources