Results 31 to 40 of about 4,290,469 (326)
Remote Sensing, 2021 Impact craters are the most prominent features on the surface of the Moon, Mars, and Mercury. They play an essential role in constructing lunar bases, the dating of Mars and Mercury, and the surface exploration of other celestial bodies.
Yutong Jia +7 more
doaj +1 more source
Slow conduction and gap junction remodeling in murine ventricle after chronic alcohol ingestion
Journal of Biomedical Science, 2011 Background Long-term heavy alcohol drinkers are prone to the development of cardiac arrhythmia. To understand the mechanisms, we evaluated the cardiac structural and electrophysiological changes in mice chronically drinking excessive alcohol.
Tsai Cheng-Ho +7 more
doaj +1 more source
Nature Communications, 2020 Oncogene amplification, a major driver of cancer pathogenicity, is often mediated through focal amplification of genomic segments. Recent results implicate extrachromosomal DNA (ecDNA) as the primary driver of focal copy number amplification (fCNA ...
J. Luebeck +11 more
semanticscholar +1 more source
Electromechanical optical mapping
Progress in Biophysics and Molecular Biology, 2017 Optical mapping is a widely used imaging technique for investigating cardiac electrophysiology in intact, Langendorff-perfused hearts. Mechanical contraction of cardiac tissue, however, may result in severe motion artifacts and significant distortion of the fluorescence signals.
Christoph, J. +2 more
openaire +4 more sources
Optical map guided genome assembly [PDF]
BMC Bioinformatics, 2020 AbstractBackgroundThe long reads produced by third generation sequencing technologies have significantly boosted the results of genome assembly but still, genome-wide assemblies solely based on read data cannot be produced. Thus, for example, optical mapping data has been used to further improve genome assemblies but it has mostly been applied in a ...
Miika Leinonen, Leena Salmela
openaire +4 more sources
Biomedicines, 2022 The severe doxorubicin (DOXO) side effect of cardiomyopathy limits it clinical application as an effective anticancer drug. Although Ca2+ overload was postulated as one of the mechanisms for this toxicity, its role was, however, disputable in terms of ...
Jingjing Wu +7 more
doaj +1 more source
CCD-based imaging and 3D space--time mapping of terahertz fields via Kerr frequency conversion [PDF]
, 2013 We investigate the spatially and temporally resolved four-wave mixing of terahertz (THz) fields and optical pulses in large-bandgap dielectrics, such as diamond. We show that it is possible to perform beam profiling and space–time resolved mapping of THz
Chan +25 more
core +1 more source
Optical genome mapping for detection of chromosomal aberrations in prenatal diagnosis
Acta Obstetricia et Gynecologica Scandinavica, 2023 Introduction Chromosomal aberrations are the most important etiological factors for birth defects. Optical genome mapping is a novel cytogenetic tool for detecting a broad range of chromosomal aberrations in a single assay, but relevant clinical ...
Qinxin Zhang +12 more
doaj +1 more source
Refinement of optical map assemblies [PDF]
Bioinformatics, 2006 Abstract Motivation: Genomic mutations and variations provide insightful information about the functionality of sequence elements and their association with human diseases. Traditionally, variations are identified through analysis of short DNA sequences, usually shorter than 1000 bp per fragment. Optical maps provide both faster and more
Anton, Valouev +3 more
openaire +2 more sources
Frontiers in Physiology, 2013 Alternans of action potential duration has been associated with T-wave alternans and the development of arrhythmias because it produces large gradients of repolarization. However, little is known about alternans dynamics in large mammalian hearts.
Alessio eGizzi +5 more
doaj +1 more source