Results 81 to 90 of about 576,432 (292)

Cardiac Optogenetics and Optical Mapping – Overcoming Spectral Congestion in All-Optical Cardiac Electrophysiology

Frontiers in Physiology, 2019
Optogenetic control of the heart is an emergent technology that offers unparalleled spatio-temporal control of cardiac dynamics via light-sensitive ion pumps and channels (opsins). This fast-evolving technique holds broad scope in both clinical and basic
Christopher O’Shea, Christopher O’Shea, Christopher O’Shea, Andrew P. Holmes, Andrew P. Holmes, James Winter, Joao Correia, Xianhong Ou, Ruirui Dong, Shicheng He, Paulus Kirchhof, Paulus Kirchhof, Larissa Fabritz, Larissa Fabritz, Kashif Rajpoot, Davor Pavlovic   +15 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Efficient Image Registration for Underwater Optical Mapping Using Geometric Invariants

Journal of Marine Science and Engineering, 2019
Image registration is one of the most fundamental and widely used tools in optical mapping applications. It is mostly achieved by extracting and matching salient points (features) described by vectors (feature descriptors) from images. While matching the
Armagan Elibol, Nak Young Chong
doaj   +1 more source

Exceptional Point Engineered Glass Slide for Microscopic Thermal Mapping

, 2017
Thermal sensing with fine spatial resolution is important to the study of many scientific areas. While modern microscopy systems allow easy optical detection at high spatial resolution, their intrinsic functions are mainly focused on imaging but limited ...
Chen, Zhaowei, Feng, Liang, Zhao, Han, Zhao, Ruogang   +3 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Synapse-specific inhibitory control of hippocampal feedback inhibitory circuit

Frontiers in Cellular Neuroscience, 2010
Local circuit and long-range GABAergic projections provide powerful inhibitory control over the operation of hippocampal inhibitory circuits, yet little is known about the input- and target-specific organization of interacting inhibitory networks in ...
Simon eChamberland, Simon eChamberland, Charleen eSalesse, Charleen eSalesse, Dimitry eTopolnik, Lisa eTopolnik, Lisa eTopolnik   +6 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Optical Mapping Near-eye Three-dimensional Display with Correct Focus Cues

, 2017
We present an optical mapping near-eye (OMNI) three-dimensional display method for wearable devices. By dividing a display screen into different sub-panels and optically mapping them to various depths, we create a multiplane volumetric image with correct
Cui, Wei, Gao, Liang
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Optical Calibration of a Multi-Color Ellipsometric Mapping Tool Fabricated Using Cheap Parts

Photonics
We developed and applied a new calibration method to make more accurate measurements with our multi-color ellipsometric mapping tool made from cheap parts.
Berhane Nugusse Zereay, Sándor Kálvin, György Juhász, Csaba Major, Péter Petrik, Zoltán György Horváth, Miklós Fried   +6 more
doaj   +1 more source