Results 71 to 80 of about 8,001,162 (292)

Ultrathin photonic–plasmonic membranes supporting high-Q hybrid bound states in the continuum

Science and Technology of Advanced Materials: Methods
Plasmonic bound states in the continuum (BICs) offer a promising route to overcome the intrinsic trade-off between field confinement and radiation loss in nanophotonic systems.
Ya-Lun Ho, Mu-Hsin Chen, Chih-Zong Deng, Chun-Hao Chiang, Hsin-Chang Lin, Yen-Ju Wu, Masanobu Iwanaga   +6 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Reflection from a free carrier front via an intraband indirect photonic transition

Nature Communications, 2018
Here the authors present an experimental demonstration of a free carrier front induced intraband indirect photonic transition and show how the waveguide dispersion can be exploited to decrease the required free carrier concentration for substantial ...
Mahmoud A. Gaafar, Dirk Jalas, Liam O’Faolain, Juntao Li, Thomas F. Krauss, Alexander Yu. Petrov, Manfred Eich   +6 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Organic molecular nonlinear optical materials and devices

, 2017
This chapter introduces the basic principles of nonlinear optical effects in organic materials. Various types of nonlinear optical processes are included, together with an overview of most important applications.
Günter, Peter, Jazbinsek, Mojca
core   +2 more sources

Author Correction: Reflection from a free carrier front via an intraband indirect photonic transition

Nature Communications, 2018
The original version of this article contained an error in first sentence of the Acknowledgements, which incorrectly read ‘M.A.G, D.J., A.Y.P. and M.E. acknowledge the support of the German Research Foundation under grant no.
Mahmoud A. Gaafar, Dirk Jalas, Liam O’Faolain, Juntao Li, Thomas F. Krauss, Alexander Yu. Petrov, Manfred Eich   +6 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Fabrication of β-Ga2O3/air-gap structures on (001) β-Ga2O3 using HCl gas etching

Science and Technology of Advanced Materials: Methods
β-Ga2O3/air-gap structures were fabricated on (001) substrates via crystallographic etching with HCl gas. Etching at 650 °C under an HCl partial pressure of 250 Pa resulted in a vertical etch rate of 0.10 μm/min on the (001) plane and a lateral etch rate
Takayoshi Oshima, Yuichi Oshima
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source