Results 61 to 70 of about 176,830 (290)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Optimization for UAV-assisted simultaneous transmission and reception communications in the existence of malicious jammers

Security and Safety
In this paper, we study an unmanned aerial vehicle (UAV)-assisted communication system, where the UAV is dispatched to implement simultaneous transmission and reception (STR) in the existence of multiple malicious jammers.
Huang Zhiyu, Liu Shuzhen, Sheng Zhichao, Yu Hongwen, Masaracchia Antonino   +4 more
doaj   +1 more source

Improved Power Budget of 112 Gb/s/$\lambda$ Intra-Datacentre Links Using a Split-Carrier Transmitter Architecture

IEEE Photonics Journal, 2019
A split-carrier transmitter is proposed to improve loss budget for short distance 100 G-per-wavelength intra-datacentre links. By applying a low-complexity hardware modification to the transmitter, the proposed architecture reduces transmitter ...
Thomas Gerard, Zhixin Liu, M. Sezer Erkilinc, Lidia Galdino, Polina Bayvel, Benn Thomsen, Domanic Lavery   +6 more
doaj   +1 more source

AgileDCN: An Agile Reconfigurable Optical Data Center Network Architecture [PDF]

, 2020
Dinh Danh Le, Liam P. Barry, Daniel C. Kilper, Philip Perry, Jingyan Wang, Conor McArdle   +5 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

System Performance Optimization of Frequency-Swept Pump-Based Rectangular Brillouin Optical Filter

IEEE Photonics Journal, 2017
In this paper, we realize a series of 2-GHz wide rectangular optical filters based on the stimulated Brillouin scattering (SBS) effect in optical fiber with a frequency-swept pump and gain feedback compensation scheme.
M. Shi, L. Yi, W. Wei, G. Pu, W. Hu
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Flexible Baseband-Unit Aggregation Enabled by Reconfigurable Multi-IF Over WDM Fronthaul

IEEE Photonics Journal, 2018
In cloud-radio access network, baseband-unit (BBU) aggregation schemes have been intensively discussed to improve the efficiency of resources in light traffic times.
Haiyun Xin, Hao He, Kuo Zhang, Syed Baqar Hussain, Weisheng Hu   +4 more
doaj   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source