Results 81 to 90 of about 9,174,095 (260)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Evaluation of corneal biomechanical properties following penetrating keratoplasty using ocular response analyzer

Indian Journal of Ophthalmology, 2014
Purpose: To evaluate corneal biomechanical properties in eyes that has undergone penetrating keratoplasty (PK). Materials and Methods: Retrospective observational study in a tertiary care centre.
Vanathi Murugesan, Ravi Bypareddy, Mahesh Kumar, Dada Tanuj, Panda Anita   +4 more
doaj   +1 more source

Density of optical degrees of freedom : intensity, linear and angular momentum [PDF]

, 2014
For any optical system, optical eigenmodes describe solutions of Maxwells equations that are orthogonal to each other. In their simplest free space form, these modes correspond, for example, to Bessel, Laguerre-Gaussian or Hermite-Gaussian beams. However,
Michael Mazilu, Mazilu, Michael
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Comparison of objective visual quality between SMILE and FS-LASIK in moderate-to-high myopia

Frontiers in Medicine
PurposeThis study aims to compare the changes in the corneal wavefront aberrations and the objective visual quality resulting from two types of eye surgery—small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (
Huaxian Zou, Huaxian Zou, Xianxian Wei, Xianxian Wei, Lili Li, Diefeng Wei, Hejuan Mao, Yanyan Huang, Pengfei Lu, Ziyu Li, Dedong Zhong, Qi Chen   +11 more
doaj   +1 more source

Minimally invasive strabismus surgery versus paralimbal approach: A randomized, parallel design study is minimally invasive strabismus surgery worth the effort?

Indian Journal of Ophthalmology, 2014
Introduction : Minimal access surgery is common in all fields of medicine. We compared a new minimally invasive strabismus surgery (MISS) approach with a standard paralimbal strabismus surgery (SPSS) approach in terms of post-operative course.
Richa Sharma, Abadan K Amitava, Sadat AO Bani   +2 more
doaj   +1 more source

Green-pumped, picosecond MgO:PPLN optical parametric oscillator

, 2011
We investigate the performance of a magnesium-oxide-doped periodically poled lithium niobate crystal (MgO:PPLN) in an optical parametric oscillator (OPO) synchronously-pumped by 530nm, 20ps, 230MHz pulses with an average power of up to 2W from a ...
Florian Kienle, Dejiao Lin, Lin, Dejiao, David J. Richardson, Major, Huw, Richardson, David J., Kienle, Florian, Shepherd, David P., Shaif-ul Alam, Gawith, Corin B.E., Corin B. E. Gawith, Hung, Hazel, Huw E. Major, Alam, Shaif-ul, David P. Shepherd, Hazel S. S. Hung   +15 more
core   +1 more source

Packet-Layer Forward Error Correction Coding for Fading Mitigation [PDF]

, 2006
In an on/off-keying atmospheric optical communication system, index of refraction turbulence and PAT (pointing, acquisition and tracking) instabilities create strong and very slow fading compared to the usually used high data-rates.
Hennes Henniger, Henniger, Hennes
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Architecture, design, and modeling of the OPSnet asynchronous optical packet switching node [PDF]

, 2005
An all-optical packet-switched network supporting multiple services represents a long-term goal for network operators and service providers alike.
Vanderbauwhede, W.A., Vanderbauwhede, W., Harle, DA, Harle, D.A., Vanderbauwhede, WA   +4 more
core   +1 more source