Results 101 to 110 of about 1,364,074 (300)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Linezolid-induced optic neuropathy

Indian Journal of Ophthalmology, 2014
Many systemic antimicrobials have been implicated to cause ocular adverse effects. This is especially relevant in multidrug therapy where more than one drug can cause a similar ocular adverse effect.
Divya Karuppannasamy, Andavar Raghuram, Devisundaram Sundar   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Clinical features and outcomes of vitrectomy in pediatric ocular injuries-eye injury vitrectomy study

Indian Journal of Ophthalmology, 2014
Context: Severe pediatric ocular injury remains a frequent and difficult problem. Vitrectomy is a major technique that has been used to manage severely damaged eyes. However, limited follow-up studies exist currently.
Xuefeng Feng, Kang Feng, Yuntao Hu, Zhizhong Ma   +3 more
doaj   +1 more source

The influence of temporal coherence on the dynamical Casimir effect

, 2010
We study the dynamical Casimir effect in the presence of a finite coherence time, which is associated with a finite quality factor of the optical cavity. We use the time refraction model, where a fixed cavity with a modulated optical medium, replaces the
Barnett, Dezael, Dodonov, Dodonov, Fox, G. Brodin, Gea-Banacloche, J.T. Mendonça, Kim, Lambrecht, Law, M. Marklund, Mendonça, Mendonça, Mendonça, Milonni, Schaller, Srivastava   +17 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Is being female a risk factor for shallow anterior chamber? The associations between anterior chamber depth and age, sex, and body height

Indian Journal of Ophthalmology, 2014
Aim of Study: To analyze the association between anterior chamber depth (ACD) and age, sex, and body height (BH). Materials and Methods: One thousand four hundred eighty eyes of 1480 adults 40 years of age and older receiving preoperative evaluation for ...
Wei-Cherng Hsu, Elizabeth P Shen, Yi-Ting Hsieh   +2 more
doaj   +1 more source

Electrically Tunable Excitonic Light Emitting Diodes based on Monolayer WSe2 p-n Junctions

, 2014
Light-emitting diodes are of importance for lighting, displays, optical interconnects, logic and sensors. Hence the development of new systems that allow improvements in their efficiency, spectral properties, compactness and integrability could have ...
A Splendiani, Aaron M. Jones, AM Jones, D Lagarde, D Mann, D Xiao, D. G. Mandrus, David H. Cobden, F Xia, G Kioseoglou, G Shambat, H Shi, H Yuan, H Zeng, J Chen, J Feng, J-K Huang, Jason S. Ross, Jiaqiang Yan, JS Ross, Kenji Kitamura, Kenji Watanabe, KF Mak, KF Mak, KF Mak, KS Novoselov, L Marty, Nirmal J. Ghimire, O Lopez-Sanchez, Philip Klement, RS Sundaram, S Essig, S Sim, T Cao, T Korn, T Mueller, Takashi Taniguchi, W Yao, W Zhao, Wang Yao, Xiaodong Xu, Z Yin, ZY Zhu   +42 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source