Results 91 to 100 of about 9,174,095 (260)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Objective Depth-of-Focus Estimation from Wavefront Measurements After Implantation of an Isofocal Intraocular Lens

Clinical Ophthalmology
Mohamed Hosny,1,2 Sarah Azzam,1,2 Ahmed Ibrahim Howaidy,2,3 Rawan Hosny,1,2 Mohamed Anis1,2 1Department of Ophthalmology, Cairo University, Cairo, Egypt; 2Dar El Oyoun Specialized Eye Hospital, Cairo, Egypt; 3Department of Ophthalmology, Aswan University,
Hosny M, Azzam S, Howaidy AI, Hosny R, Anis M   +4 more
doaj  

Aberrometric analysis and visual results of patients undergoing Transepithelial photorefractive keratectomy: Safety, effectiveness, and optical quality

The Pan-American Journal of Ophthalmology
Background: Transphotorefractive keratectomy (tPRK) is an evolving surface ablation technique for the correction of myopia that avoids flap-related complications while aiming to provide excellent refractive outcomes.
Carlos Eduardo X. Da Cunha, Stéphanie Pessoa Regueira, Isabela A. Vilela, Fernando A. C. B. Carvalho Neto, Marilia Leal Oliveira, Camila V. Ventura, Emerson I. Morishita, Camila De Moraes Costa Barros   +7 more
doaj   +1 more source

Optical interconnection networks based on microring resonators [PDF]

, 2012
Optical microring resonators can be integrated on a chip to perform switching operations directly in the optical domain. Thus they become a building block to create switching elements in on-chip optical interconnection networks, which promise to overcome
Cuda, Davide, Giaccone, Paolo, GARRICH ALABARCE, MIQUEL, Garrich, M., Gaudino, Roberto, Bianco, Andrea, Gavilanes Castillo, Guido Alejandro   +6 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Optical Bench Evaluation of a Novel, Hydrophobic, Acrylic, One-Piece, Polyfocal Intraocular Lens with a “Zig-Zag” L-Loop Haptic Design

Vision
Purpose: The number of presbyopia-correcting (premium) intraocular lenses (IOLs) is growing steadily as the desire for spectacle independence after cataract surgery increases. The aim of this laboratory study was to evaluate a newly launched hydrophobic,
Andreas F. Borkenstein, Eva-Maria Borkenstein, Pooria Omidi, Achim Langenbucher   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

On-Chip Integrated Label-Free Optical Biosensing [PDF]

, 2013
This thesis investigates the design and implementation of a label-free optical biosensing system utilizing a robust on-chip integrated platform. The goal has been to transition optical micro-resonator based label-free biosensing from a laborious and ...
Sendowski, Jacob Benjamin
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source