Results 81 to 90 of about 238 (195)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Lie group analysis, solitons, self-adjointness and conservation laws of the nonlinear elastic structural element equation

Journal of Taibah University for Science
This study is based on the Lie group method for the nonlinear elastic structural element equation (ESE Equation). We obtain a three-dimensional Lie algebra. By utilizing this Lie algebra a four-dimensional optimal system is constructed. The governing ESE
Akhtar Hussain, Muhammad Usman, Fiazuddin Zaman   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Closed-Form Heteroclinic Orbits for a Three-Parameter Dynamical System Using a Modified Optimal Parametric Iteration Method

Mathematics
Numerous applications from electrical engineering and mechanical structures are mathematically modeled using dynamical systems theory. Our paper concerns the behaviors of a 3D dynamic system in terms of damped or periodical oscillations and asymptotic ...
Remus-Daniel Ene, Romeo Negrea, Rodica Badarau, Nicolina Pop   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Optimal Auxiliary Functions Method for Semi-Analytical Solutions of the MHD Mixed Convection Stagnation-Point Flow Problem

Symmetry
The present paper treats the problem of steady laminar MHD flow of an incompressible viscous fluid for mixed convection stagnation-point flow over a vertical stretching sheet in the presence of an externally magnetic field. By means of the Optimal Auxiliary Functions Method (OAFM), the resulting nonlinear ODEs are semi-analytically solved.
Remus-Daniel Ene, Nicolina Pop, Rodica Badarau   +2 more
openaire   +1 more source

On the Nonlinear Forced Vibration of the Magnetostrictive Laminated Beam in a Complex Environment

Mathematics
The present study dealt with a comprehensive mathematical model to explore the nonlinear forced vibration of a magnetostrictive laminated beam.
Nicolae Herisanu, Bogdan Marinca, Vasile Marinca   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Comparative study of fractional Newell–Whitehead–Segel equation using optimal auxiliary function method and a novel iterative approach

AIP Advances
This research explores the solution of the time-fractional Newell–Whitehead–Segel equation using two separate methods: the optimal auxiliary function method and a new iterative method. The Newell–Whitehead–Segel equation holds significance in modeling nonlinear systems, particularly in delineating stripe patterns within two-dimensional systems ...
Xiao Xin, Ibrar khan, Abdul Hamid Ganie, Ali Akgül, Ebenezer Bonyah, Dowlath Fathima, Badria Almaz Ali Yousif   +6 more
openaire   +3 more sources

Using of Modified Simplex Imbeddings Method for Solving Special Class of Convex Non-Differentiable Optimization Problems

Известия Иркутского государственного университета: Серия "Математика", 2015
In this paper it is considered the modified simplex imbeddings method, which is related to the class of cutting plane methods. The main feature of this method is the convergence estimation, which depends only on the quantity of simplex vertices, that are
A.V. Kolosnitcyn
doaj