Results 51 to 60 of about 12,436,371 (298)

Optimal control problems for nonlinear parabolic boundary control systems: the Dirichlet boundary condition

Differential and Integral Equations, 1994
A boundary control system described by a semilinear partial differential heat equation is considered. The control is applied through the forced Dirichlet boundary condition. The optimal control problem is that of minimizing a cost functional among all determined admissible controls for which the corresponding solutions satisfy a given target condition.
Fattorini, H. O., Murphy, T.
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

On an inverse boundary control of a system of integro-differential equations of fractional order in a locally convex space

Қарағанды университетінің хабаршысы. Математика сериясы
This paper investigates an inverse boundary optimal control problem for a nonlinear system of fractionalorder integro-differential equations in a complete locally convex space.
T.K. Yuldashev, M.T. Kosmakova, A.N. Abdullozhonova, M.K. Mamanov   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimal boundary control of a nonstandard Cahn-Hilliard system with dynamic boundary condition and double obstacle inclusions [PDF]

, 2017
In this paper, we study an optimal boundary control problem for a model for phase separation taking place in a spatial domain that was introduced by P. Podio-Guidugli in Ric. Mat. 55 (2006), pp. 105-118. The model consists of a strongly coupled system of
Sprekels, Jürgen, Pierluigi Colli, Colli, Pierluigi, Jürgen Sprekels   +3 more
core   +1 more source

Quasi-optimal control of a solar thermal system via neural networks

Energy and AI, 2023
The optimal control of complex thermal energy systems is a challenge due to their dynamic behavior and constantly changing boundary conditions. To maximize the energy efficiency of such a dynamic system, optimal trajectories for the controlled variables ...
Jana Friese, Niklas Brandt, Andreas Schulte, Christian Kirches, Wilhelm Tegethoff, Jürgen Köhler   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Transient growth in the flow past a three-dimensional smooth roughness element [PDF]

, 2013
This work provides a global optimization analysis, looking for perturbations inducing the largest energy growth at a finite time in a boundary-layer flow in the presence of smooth three-dimensional roughness elements.
DE TULLIO, Marco, PASCAZIO, Giuseppe, DE PALMA, Pietro, CHERUBINI, Stefania, DE TULLIO, Marco Donato   +4 more
core   +1 more source

Optimal boundary control for a time dependent thermistor problem

Electronic Journal of Differential Equations, 2009
An optimal control of a two dimensional time dependent thermistor problem is considered. The problem consists of two nonlinear partial differential equations coupled with appropriate boundary conditions which model the coupling of the thermistor to ...
Volodymyr Hrynkiv
doaj