Results 81 to 90 of about 356,969 (310)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Data Layout Optimizations for Variable Coefficient Multigrid [PDF]

open access: yes, 2002
Efficient program execution can only be achieved if the codes respect the hierarchical memory design of the underlying architectures; programs must exploit caches to avoid high latencies involved with main memory accesses. However, iterative methods like multigrid are characterized by successive sweeps over data sets, which are commonly too large to ...
Markus Kowarschik   +2 more
openaire   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Topological errors and optimal chamfer distance coefficients [PDF]

open access: yes, 1997
In this paper, a theoretical characterisation of the topological errors which arise during the approximation of Euclidean distances from discrete ones is presented. The continuous distance considered is the widely used Euclidean distance whereas we consider as discrete distance the chamfer distance based on 3 x 3 masks.
Stéphane Marchand-Maillet   +1 more
openaire   +1 more source

The Optimal Inflation Rate in New Keynesian Models [PDF]

open access: yes
We study the effects of positive steady-state inflation in New Keynesian models subject to the zero bound on interest rates. We derive the utility-based welfare loss function taking into account the effects of positive steady-state inflation and show ...
Olivier Coibion   +2 more
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

A hybrid procedure to identify the optimal stiffness coefficients of elastically restrained beams

open access: yesInternational Journal of Applied Mathematics and Computer Science, 2015
The formulation of a bending vibration problem of an elastically restrained Bernoulli-Euler beam carrying a finite number of concentrated elements along its length is presented.
Silva Tiago   +3 more
doaj   +1 more source

Optimal Choice of Monetary Policy Instruments in a Macroeconometric Model [PDF]

open access: yes
This paper uses stochastic simulation and my U.S. econometric model to examine the optimal choice of monetary policy instruments. Are the variances, covariances, and parameters in the model such as to favor one instrument over the other, in particular ...
Ray C. Fair
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

ON UNBOUNDED OPTIMAL CONTROLS IN COEFFICIENTS FOR ILL-POSED ELLIPTIC DIRICHLET BOUNDARY VALUE PROBLEMS

open access: yesVìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Modelûvannâ, 2014
We consider an optimal control problem associated to Dirichlet boundary valueproblem for linear elliptic equations on a bounded domain Ω. We take the matrixvalued coecients A(x) of such system as a control in L1(Ω;RN RN). One of the important features of
Т. Horsin, P. I. Kogut
doaj   +1 more source

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