Results 91 to 100 of about 1,760,259 (342)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Age-structured optimal control in population economics [PDF]
This paper brings both intertemporal and age-dependent features to a theory of population policy at the macro-level. A Lotkatype renewal model of population dynamics is combined with a Solow/Ramsey economy.
Alexia Prskawetz +2 more
core
Collision-Free Multi-UAV Optimal Path Planning and Cooperative Control for Tactical Applications [PDF]
, 2008 AIAA Guidance, Navigation and Control Conference and Exhibit 18 - 21 August 2008, Honolulu, HawaiiStemming from previous work that addressed the optimal path planning of an unmanned aerial vehicle (UAV) in obstacle-rich environments, this paper ...
Lewis, L. Ryan +3 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Immunotherapy: An Optimal Control Theory Approach
Mathematical Biosciences and Engineering, 2005 We investigate mathematical models for the dynamics between tumor cells, immune-effector cells, and cytokine interleukin-2 (IL-2). To better determine under what circumstances the tumor can be eliminated, we implement optimal control theory. We design two control functionals, the first functional having one control and the second having two controls ...
K. Renee Fister +1 more
openaire +3 more sources
Optimal control and robust estimation for ocean wave energy converters [PDF]
, 2013 This thesis deals with the optimal control of wave energy converters and some associated observer design problems. The first part of the thesis will investigate model predictive control of an ocean wave energy converter to maximize extracted power.
Abraham, Edo
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
New approach to stochastic optimal control and applications to economics [PDF]
, 2005 This paper provides new insights into the solution of optimal stochastic control problems by means of a system of partial differential equations, which characterize directly the optimal control.
Rincón-Zapatero, Juan Pablo +1 more
core