Results 91 to 100 of about 19,271,700 (291)
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Nonessential functionals in multiobjective optimal control problems [PDF]
, 2007 We address the problem of obtaining well-defined criteria for multiple criteria optimal control problems. Necessary and sufficient conditions for an objective functional to be nonessential are proved.
Malinowska, A.B. +3 more
core +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
, 1982 Theory and Application of Digital Control contains the proceedings of the IFAC Symposium held at New Delhi, India on January 5-7, 1982. This book particularly presents the texts of the five plenary talks and the 110 papers of the symposium.
International Federation of Automatic Control +2 more
core
Optimal Control of Endemic Epidemic Diseases With Behavioral Response
IEEE Open Journal of Control SystemsBehavioral factors play a crucial role in the emergence, spread, and containment of human diseases, significantly influencing the effectiveness of intervention measures.
Francesco Parino +2 more
doaj +1 more source
Analysis of fractional order model on higher institution students' anxiety towards mathematics with optimal control theory. [PDF]
Sci Rep, 2023 Teklu SW.
europepmc +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
The impact of spatial arrangements on epidemic disease dynamics and intervention strategies
Journal of Biological Dynamics, 2016 The role of spatial arrangements on the spread and management strategies of a cholera epidemic is investigated. We consider the effect of human and pathogen movement on optimal vaccination strategies.
Michael R. Kelly +3 more
doaj +1 more source