Results 111 to 120 of about 1,760,259 (342)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Analysis of fractional order model on higher institution students' anxiety towards mathematics with optimal control theory. [PDF]
Sci Rep, 2023 Teklu SW.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Application of fractional optimal control theory for the mitigating of novel coronavirus in Algeria. [PDF]
Results Phys, 2022 El Hadj Moussa Y +4 more
europepmc +1 more source
Optimal Control Theory for Undergraduates
Dynamic optimization is widely used in financial economics, macroeconomics and resource economics. This is accounting for some tension between the undergraduate and graduate teaching of economics because most undergraduate programs still concentrate on ...
Ernst Juerg Weber
core
Nonessential functionals in multiobjective optimal control problems
, 2007 We address the problem of obtaining well-defined criteria for multiple criteria optimal control problems. Necessary and sufficient conditions for an objective functional to be nonessential are proved.
Malinowska, A.B. +3 more
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
An optimal control theory approach for freight structure path evolution post-COVID-19 pandemic. [PDF]
Socioecon Plann Sci, 2023 Lu C, Ye Y, Fang Y, Fang J.
europepmc +1 more source
Quadratures of Pontryagin extremals for optimal control problems
, 2006 We obtain a method to compute effective first integrals by combining Noether's principle with the Kozlov-Kolesnikov integrability theorem. A sufficient condition for the integrability by quadratures of optimal control problems with controls taking values
Rocha, E. A. +3 more
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source