Results 121 to 130 of about 1,760,259 (342)

A minmax problem for parabolic systems with competitive interactions

Electronic Journal of Differential Equations, 1999
In this paper we model the evolution and interaction between two competing populations as a system of parabolic partial differential equations. The interaction between the two populations is quantified by the presence of non-local terms in the system of ...
Sanjay Chawla
doaj  

Mathematical modeling analysis on the dynamics of university students animosity towards mathematics with optimal control theory. [PDF]

Sci Rep, 2022
Teklu SW, Terefe BB.
europepmc   +1 more source

The Reproductive Value in Distributed Optimal Control Models [PDF]

We show that in a large class of distributed optimal control models (DOCM), where population is described by a McKendrick type equation with an endogenous number of newborns, the reproductive value of Fisher shows up as part of the shadow price of the ...
Michael Kuhn, Stefan Wrzaczek, Alexia Prskawetz, Gustav Feichtinger   +3 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Stochastic linear regulator problem in optimal control theory: Stochastic optimal linear regulator problem

, 2012
Stochastic optimization problems are the study of dynamical systems subject to random perturbations which can be controlled in order to optimize some performance criterion.
Baten, Md Azizul
core  

The geometry of the solution set of nonlinear optimal control problems

, 2005
In an optimal control problem one seeks a time-varying input to a dynamical systems in order to stabilize a given target trajectory, such that a particular cost function is minimized.
Osinga, HM, Hauser, J
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

An efficient model‐free adaptive optimal control of continuous‐time nonlinear non‐zero‐sum games based on integral reinforcement learning with exploration

IET Control Theory & Applications
To reduce the learning time and space occupation, this study presents a novel model‐free algorithm for obtaining the Nash equilibrium solution of continuous‐time nonlinear non‐zero‐sum games.
Lei Guo, Wenbo Xiong, Yuan Song, Dongming Gan   +3 more
doaj   +1 more source

Optimal control of non-stationary differential linear repetitive processes

, 2008
Differential repetitive processes are a distinct class of continuous discrete 2D linear systems of both systems theoretic and applications interest. The feature which makes them distinct from other classes of such systems is the fact that information ...
Rogers, E, M. Dymkov, Dymkov, M, K. Galkowski, E. Rogers, Galkowski, K, Dymkou, S, S. Dymkou   +7 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source