Results 71 to 80 of about 19,271,700 (291)
Optimal Control Theory for Undergraduates [PDF]
Dynamic optimization is widely used in financial economics, macroeconomics and resource economics. This is accounting for some tension between the undergraduate and graduate teaching of economics because most undergraduate programs still concentrate on ...
Ernst Juerg Weber
core
Mitigating controller noise in quantum gates using optimal control theory [PDF]
QuantumAll quantum systems are subject to noise from the environment or external controls. This noise is a major obstacle to the realization of quantum technology. For example, noise limits the fidelity of quantum gates.
Aviv Aroch +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Convergence of Pseudospectral Discretization of Optimal Control Problems [PDF]
, 2001 The article of record as published may be located at http://ieeexplore.ieee.orgProceedings of the 40th IEEE Conference on Decision and Control ; Orlando, Florida USA, December 2001A generic nonlinear optimal control problem with a Bolza cost functional ...
Fahroo, Fariba, Ross, I. Michael
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Controlling rabies epidemics in Nepal with limited resources: optimal control theory approach
Mathematics in Applied Sciences and Engineering, 2020 In many developing countries, including Nepal, rabies epidemics constitute a serious public health concern, partly because of limited resources for proper implementation of control measures.
Buddhi Pantha, Hem Joshi, Naveen Vaidya
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Exact penalty functions for optimal control problems [PDF]
openA novel technique to solve optimal control problems with state constraints is proposed. We exploit the theory of exact penalty functions, used in mathematical programming, to construct a systematic procedure to transform two classes of problems with ...
GRIMALDI, RICCARDO ALESSANDRO
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Quadratures of Pontryagin extremals for optimal control problems [PDF]
, 2006 We obtain a method to compute effective first integrals by combining Noether's principle with the Kozlov-Kolesnikov integrability theorem. A sufficient condition for the integrability by quadratures of optimal control problems with controls taking values
Rocha, E. A. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source