Results 61 to 70 of about 19,271,700 (291)
Collision-Free Multi-UAV Optimal Path Planning and Cooperative Control for Tactical Applications [PDF]
AIAA Guidance, Navigation and Control Conference and Exhibit 18 - 21 August 2008, Honolulu, HawaiiStemming from previous work that addressed the optimal path planning of an unmanned aerial vehicle (UAV) in obstacle-rich environments, this paper ...
Kevin Bollino +3 more
core +1 more source
In this paper, we present connections between recent developments on the linearly-solvable stochastic optimal control framework with early work in control theory based on the fundamental dualities between free energy and relative entropy. We extend these
Evangelos A. Theodorou
doaj +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Controllability and Optimal Control of Microswimmers: Theory and Applications
The process of swimming at the microscopic scale is successfully described as a finite-dimensional, nonholonomic control system due to negligible inertia in the low-Reynolds number regime that holds for objects this size. The study of such systems from the point of view of mathematical control theory yields fundamental results on elementary swimmer ...
openaire +2 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Heteroclinic optimal control solutions for attitude motion planning [PDF]
An analytical attitude motion planning method is presented that exploits the heteroclinic connections of an optimal kinematic control problem. This class of motion, of hyperbolic type, supply a special case of analytically defined rotations that can be ...
Biggs, James +7 more
core +1 more source
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
An optimal gains matrix for time-delay feedback control [PDF]
In this paper we propose an optimal time-delayed feedback control (TDFC) for tracking unstable periodic orbits (UPOs). It is shown that TDFC will drive a trajectory onto a periodic orbit while minimising an integral of a cost function of the error in ...
Biggs, James +6 more
core +1 more source
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source

