Results 51 to 60 of about 19,271,700 (291)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

State elimination for mixed‐integer optimal control of partial differential equations by semigroup theory [PDF]

open access: yes, 2022
Mixed-integer optimal control problems governed by partial differential equations (MIPDECOs) are powerful modeling tools but also challenging in terms of theory and computation.
Sebastian Sager   +5 more
core   +1 more source

On the optimal game control in the DC microgrid systems

open access: yesIET Renewable Power Generation
This paper introduces static and dynamic competitive optimal control of DC/DC converters in DC microgrids based on game theory considering mutual effects.
Zahra Mokhtarnejad, Jalal Nazarzadeh
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Second-law-like inequalities with information and their interpretations

open access: yesNew Journal of Physics, 2014
In a thermodynamic process with measurement and feedback, the second law of thermodynamics is no longer valid. In its place, various second-law-like inequalities have been advanced that each incorporate a distinct additional term accounting for the ...
Jordan M Horowitz, Henrik Sandberg
doaj   +1 more source

Hurdle-Hop Simulation of Tilt-Rotor Aircraft Based on Optimal Control Theory

open access: yesXibei Gongye Daxue Xuebao, 2020
Aiming at simulating the hurdle-hop of tilt-rotor aircraft in forward flight near the ground, two models of numerical simulation and analysis based on optimal control theory were proposed.

doaj   +1 more source

A survey of adaptive optimal control theory

open access: yesMathematical Biosciences and Engineering, 2022
<abstract><p>This paper makes a survey about the recent development of optimal control based on adaptive dynamic programming (ADP). First of all, based on DP algorithm and reinforcement learning (RL) algorithm, the origin and development of the optimization idea and its application in the control field are introduced.
Xiaoxuan Pei, Kewen Li, Yongming Li
openaire   +3 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

An optimality theory of concurrency control for databases [PDF]

open access: yesActa Informatica, 1979
A concurrency control mechanism (or a scheduler) is the component of a database system that safeguards the consistency of the database in the presence of interleaved accesses and update requests. We formally show that the performance of a scheduler, i.e., the amount of parallelism that it supports, depends explicitly upon the amount of information that
H. T. Kung 0001   +1 more
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

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