Results 51 to 60 of about 2,865,260 (284)
Cancer Informatics, 2015 Data quality is a recognized problem for high-throughput genomics platforms, as evinced by the proliferation of methods attempting to filter out lower quality data points.
Kevin K. Mcdade +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Impact of adaptive filtering on power and false discovery rate in RNA-seq experiments
BMC Bioinformatics, 2022 Background In RNA-sequencing studies a large number of hypothesis tests are performed to compare the differential expression of genes between several conditions.
Sonja Zehetmayer +2 more
doaj +1 more source
On Optimal Filtering for Speech Decomposition [PDF]
2018 26th European Signal Processing Conference (EUSIPCO), 2018 Optimal linear filtering has been used extensively for speech enhancement. In this paper, we take a first step in trying to apply linear filtering to the decomposition of a noisy speech signal into its components. The problem of decomposing speech into its voiced and unvoiced components is considered as an estimation problem.
Alfredo Esquivel Jaramillo +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Quantum Optimal Control for Coherent Spin Dynamics of Radical Pairs via Pontryagin Maximum Principle [PDF]
QuantumThis paper aims to devise the shape of the external electromagnetic field that drives the spin dynamics of radical pairs to a quantum coherent state through maximization of the triplet-born singlet yield in biochemical reactions.
Ugur G. Abdulla +2 more
doaj +1 more source
IET Electric Power Applications, 2022 This study proposes an approach for finding the optimal size of a high‐speed flywheel in an energy storage system based on battery‐flywheel cooperation, called battery‐flywheel energy storage system (BFESS), supplying an electric vehicle.
Abbas Mehraban +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Metric of choosing the optimal parameter setting for edge aware filtering
IET Image Processing, 2022 Most of the existing edge aware filters have a number of parameters. The optimal settings of these parameters guarantee the best performance but they depend on the input image.
Hui Yin, Fei Zhou, Bin Li
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source