Results 51 to 60 of about 160,246 (263)

Metric of choosing the optimal parameter setting for edge aware filtering

open access: yesIET Image Processing, 2022
Most of the existing edge aware filters have a number of parameters. The optimal settings of these parameters guarantee the best performance but they depend on the input image.
Hui Yin, Fei Zhou, Bin Li
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

An Integrated MEMS Gyroscope Array with Higher Accuracy Output

open access: yesSensors, 2008
In this paper, an integrated MEMS gyroscope array method composed of two levels of optimal filtering was designed to improve the accuracy of gyroscopes. In the firstlevel filtering, several identical gyroscopes were combined through Kalman filtering into
Weizheng Yuan   +4 more
doaj  

Optimal Gaussian Filter for Effective Noise Filtering

open access: yesCoRR, 2014
In this paper we show that the knowledge of noise statistics contaminating a signal can be effectively used to choose an optimal Gaussian filter to eliminate noise. Very specifically, we show that the additive white Gaussian noise (AWGN) contaminating a signal can be filtered best by using a Gaussian filter of specific characteristics.
Sunil Kumar Kopparapu, M. Satish
openaire   +2 more sources

Optimal Filtering in the Salamander Retina [PDF]

open access: yes, 1992
The dark-adapted visual system can count photons with a reliability limited by thermal noise in the rod photoreceptors - the processing circuitry between the rod cells and the brain is essentially noiseless and in fact may be close to optimal. Here we design an optimal signal processor which estimates the time-varying light intensity at the retina ...
Fred Rieke   +2 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

A Review of Nonlinear Filtering Algorithms in Integrated Navigation Systems

open access: yesSensors
Nonlinear filtering algorithms have significant implications in the optimal estimation of navigation states and in improving the accuracy, reliability, and robustness of navigation systems.
Jiaqian Si, Yanxiong Niu, Botao Wang
doaj   +1 more source

Optimal Kalman Filtering for a Class of State Delay Systems with Randomly Multiple Sensor Delays

open access: yesAbstract and Applied Analysis, 2014
The optimal Kalman filtering problem is investigated for a class of discrete state delay stochastic systems with randomly multiple sensor delays. The phenomenon of measurement delay occurs in a random way and the delay rate for each sensor is described ...
Dongyan Chen, Long Xu
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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