Results 81 to 90 of about 613,836 (268)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Optimal location of logistics distribution centres with swarm intelligent clustering algorithms. [PDF]
PLoS One, 2022 Lin TX, Wu ZH, Pan WT.
europepmc +1 more source
Computers & Mathematics with Applications, 1980 AbstractThe problem of finding a point on the sphere S2 = {x̄ = (x, y, z)¦x2 + y2 + z2 = 1} which minimizes the weighted sum of the distances to N given destination points x̄j on S2 is studied. Three different metrics are considered as distances between points on S2: (A), square of Euclidean distance; (B), Euclidean distance; (C), great circle distance.
Norman Katz, I., Cooper, Leon
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Entropy, 2018 This study proposed a pressure driven entropy method (PDEM) that determines a priority order of pressure gauge locations, which enables the impact of abnormal condition (e.g., pipe failures) to be quantitatively identified in water distribution networks (
Do Guen Yoo +3 more
doaj +1 more source
A novel methodology for optimal location of reactive compensation through deep neural networks. [PDF]
Heliyon, 2022 Jaramillo M, Tipán L, Muñoz J.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
THE STUDY FOR SUBSTANTIATE OPTIMAL LOCATION FOR A PROCESSING RAPESEED FACTORY IN CALARASI COUNTY [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2014 To ensure a high economic efficiency of productive work is necessary to determine the optimal location of the objective investment. Optimal location creates a prerequisite for approaching the maximum level of investment efficiency both in the national ...
Ioana NICULAE +4 more
doaj
Subthalamic deep brain stimulation for primary dystonia: defining an optimal location using the medial subthalamic nucleus border as anatomical reference. [PDF]
Front Aging Neurosci, 2023 Zhao M +12 more
europepmc +1 more source