Results 51 to 60 of about 6,241,952 (310)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Two-stage ADMM-based distributed optimal reactive power control method for wind farms considering wake effects

Global Energy Interconnection, 2021
Since the connection of small-scale wind farms to distribution networks, power grid voltage stability has been reduced with increasing wind penetration in recent years, owing to the variable reactive power consumption of wind generators. In this study, a
Zhenming Li, Zhao Xu, Yawen Xie, Donglian Qi, Jianliang Zhang   +4 more
doaj   +1 more source

A Summary of Reactive Power Optimization Algorithms [PDF]

Proceedings of the 2015 4th International Conference on Computer, Mechatronics, Control and Electronic Engineering, 2015
In order to comprehensively generalize the research status quo, achievements as well as deficiencies on the power system reactive power optimization algorithms, a universal reactive power optimization model was introduced in this paper, and a variety of common traditional optimization algorithms, artificial intelligence optimization algorithms used in ...
Kewen Wang, DongYue Zhang
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Series and shunt FACTS controllers based optimal reactive power dispatch [PDF]

Optimal reactive power dispatch involves the determination and management of reactive power resources in a power system to maintain voltage stability, improve power transfer capability, and minimize system losses.
Kar, Manoj Kumar, Dash, Subhasis, Parida, R. N. Ramakant   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A flexible and temporal integral optimal reactive power control system [PDF]

, 2004
This paper proposes a flexible and temporal integral voltage/reactive power control system. The voltage stability problem is mainly driven by the dynamics of consumers’ load demand which possesses both daily periodic character and short-term stochastic ...
Lin, M, Samarasinghe, Sandhya, Hu, A, A. P. Hu, M. Lin, S. Samarasinghe   +5 more
core  

Improved system operations with high penetration of wind power : a dialog between academia and industry - Ireland [PDF]

, 2010
Panel session submission for the IEEE Power and Energy Society (PES) 2010 General Meeting, July 25-29 2010, Minneapolis, MinnesotaThis is a submission to a panel session at the 2010 IEEE PES General Meeting. It discusses effective collaboration between
Power, Michael, Michael Power, O\u27Malley, Mark, O'Malley, Mark, Mark O'Malley   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source